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A. J. Hunter
Researcher at GlaxoSmithKline
Publications - 17
Citations - 1812
A. J. Hunter is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: SHIRPA & Mutagenesis (molecular biology technique). The author has an hindex of 12, co-authored 17 publications receiving 1725 citations. Previous affiliations of A. J. Hunter include University of Oxford.
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Journal ArticleDOI
Behavioral and functional analysis of mouse phenotype: SHIRPA, a proposed protocol for comprehensive phenotype assessment
Derek C. Rogers,Elizabeth M. C. Fisher,Steve D.M. Brown,Josephine Peters,A. J. Hunter,Joanne E. Martin +5 more
TL;DR: The SHIRPA procedure is developed, which utilizes standardized protocols for behavioral and functional assessment that provide a sensitive measure for quantifying phenotype expression in the mouse, and can be refined to test the function of specific neural pathways, which will contribute to a greater understanding of neurological disorders.
Journal ArticleDOI
Functional assessments in mice and rats after focal stroke.
A. J. Hunter,J.P. Hatcher,David Virley,P Nelson,Elaine A. Irving,Sarah J. Hadingham,Andrew A. Parsons +6 more
TL;DR: This paper presents a comprehensive assessment of sensorimotor deficits in the mouse after focal ischaemia induced by occlusion of the middle cerebral artery and rates of recovery over time were examined.
Journal ArticleDOI
5-HT6 receptor antagonists as novel cognitive enhancing agents for Alzheimer's disease.
TL;DR: It is increasingly clear that blockade of 5-HT6 receptors leads to an improvement of cognitive performance in a wide variety of learning and memory paradigms and also results in anxiolytic and antidepressant-like activity.
Journal ArticleDOI
LPA1 receptor-deficient mice have phenotypic changes observed in psychiatric disease.
Stephen M. Harrison,Charlie Reavill,G Brown,Jon T. Brown,Jane E. Cluderay,Barry Crook,Ceri H. Davies,Lee A. Dawson,Evelyn Grau,Christian Heidbreder,Panida Hemmati,Guillaume J. Hervieu,A Howarth,Zoe A. Hughes,A. J. Hunter,J. Latcham,Susan J. Pickering,Pippa L Pugh,Derek C. Rogers,Claire S. Shilliam,Peter R. Maycox +20 more
TL;DR: A marked deficit in prepulse inhibition, widespread changes in the levels and turnover of the neurotransmitter 5-HT, a brain region-specific alteration in levels of amino acids, and a craniofacial dysmorphism are revealed in these mice.