Agata Nyga

TL;DR: Current 3D in vitro models of cancer are overviewed and strategies employed by researchers to tackle these aspects with special reference to recent promising developments, as well as the current limitations of 2D cultures and in vivo models.

TL;DR: This model is characterized by the release of vascular endothelial growth factor by HT29 cells, mainly at the invading edge of the artificial cancer mass, which is fundamental in establishing a reproducible, complex model that could be used to advance understanding of cancer pathology and will facilitate therapeutic drug testing.

TL;DR: Co-NPs induce the HIF pathway by depleting intracellular ascorbate, leading to HIF stabilization and pathway activation, and a possible role for HIF in metal-on-metal hip implant pathology is suggested.

TL;DR: In this paper, the authors studied in vitro and in vivo macrophage migration during exposure to cobalt and chromium ions and nanoparticles and found that cobalt but not chromium significantly reduced the motility of macrophages and increased cell spreading, formation of intracellular podosome-type adhesion structures and enhanced cell adhesion to the extracellular matrix.

TL;DR: These results support, within a biomimetic 3D, in vitro framework, the direct role of CAFs in promoting cancer invasion, and their key function in driving vasculogenesis and angiogenesis.