Alexis Rohou

TL;DR: Modifications to the CTFFIND algorithm are described which make it significantly faster and more suitable for use with images collected using modern technologies such as dose fractionation and phase plates.

TL;DR: New open-source software called cisTEM (computational imaging system for transmission electron microscopy) for the processing of data for high-resolution electron cryo-microscopy and single-particle averaging is developed, optimized to enable processing of typical datasets on a high-end, CPU-based workstation in half a day or less, comparable to GPU-accelerated processing.

TL;DR: Cryo-EM analysis of the bovine mitochondrial ATP synthase revealed seven distinct states of the enzyme that show different modes of bending and twisting in the intact ATP synthases, suggesting a proton translocation path through the FO region that involves both the a and b subunits.

TL;DR: The model reveals that the individual layers of the Aβ fibril are formed by peptide dimers with face-to-face packing, explaining why aggregation inhibitors are most potent when targeting the C terminus, and explains how addition of C-terminal amino acids may stabilize peptide interaction.

TL;DR: It is suggested that the different sensory extensions respond to different signals, whereas the conserved domains in the core integrate the varied signals, and the architecture of the stressosome provides the potential for cooperativity.