A
Andrea Marzi
Researcher at National Institutes of Health
Publications - 161
Citations - 9636
Andrea Marzi is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Ebola virus & Vesicular stomatitis virus. The author has an hindex of 46, co-authored 133 publications receiving 7643 citations. Previous affiliations of Andrea Marzi include Public Health Agency of Canada & University of Erlangen-Nuremberg.
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Journal ArticleDOI
Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses.
TL;DR: An approach to rapidly screen lineage B betacoronaviruses, such as SARS-CoV and the recently emerged SARS -CoV-2, for receptor usage and their ability to infect cell types from different species is developed.
Journal ArticleDOI
DC-SIGN and DC-SIGNR Interact with the Glycoprotein of Marburg Virus and the S Protein of Severe Acute Respiratory Syndrome Coronavirus
Andrea Marzi,Thomas Gramberg,Graham Simmons,Peggy Möller,Andrew J. Rennekamp,Mandy Krumbiegel,Martina Geier,Jutta Eisemann,Nadine Turza,Bertrand Saunier,Alexander Steinkasserer,Stephan Becker,Paul Bates,Heike Hofmann,Stefan Pöhlmann +14 more
TL;DR: DC-SIGN and DC-SIGNR enhance infection mediated by the glycoprotein of Marburg virus and the S protein of severe acute respiratory syndrome coronavirus and might promote viral dissemination.
Journal ArticleDOI
Susceptibility to SARS coronavirus S protein-driven infection correlates with expression of angiotensin converting enzyme 2 and infection can be blocked by soluble receptor.
Heike Hofmann,Martina Geier,Andrea Marzi,Mandy Krumbiegel,Matthias Peipp,Georg H. Fey,Thomas Gramberg,Stefan Pöhlmann +7 more
TL;DR: The results point to a central role of ACE2 in SARS-CoV infection and suggest a minor contribution of the cytoplasmic domain to receptor function, which is not important for receptor function.
Journal ArticleDOI
DC-SIGN and CLEC-2 mediate human immunodeficiency virus type 1 capture by platelets
Chawaree Chaipan,Elizabeth J. Soilleux,Peter Simpson,Heike Hofmann,Heike Hofmann,Thomas Gramberg,Andrea Marzi,Martina Geier,Elizabeth A. Stewart,Jutta Eisemann,Alexander Steinkasserer,Katsue Suzuki-Inoue,Gemma L.J. Fuller,Andrew C. Pearce,Steve P. Watson,James A. Hoxie,Frédéric Baribaud,Stefan Pöhlmann +17 more
TL;DR: It is shown that platelets express both the C-type lectin-like receptor 2 (CLEC-2) and low levels of DC-SIGN, indicating that these lectins are required for efficient HIV-1 binding to platelets and providing evidence that platelet-associated virus remains infectious and can escape degradation by platelets.
Journal ArticleDOI
Antibodies are necessary for rVSV/ZEBOV-GP–mediated protection against lethal Ebola virus challenge in nonhuman primates
Andrea Marzi,Flora Engelmann,Friederike Feldmann,Kristen Haberthur,W. Lesley Shupert,Douglas Brining,Dana P. Scott,Thomas W. Geisbert,Yoshihiro Kawaoka,Michael G. Katze,Heinz Feldmann,Ilhem Messaoudi +11 more
TL;DR: It is suggested that antibodies play a critical role in rVSV-mediated protection against ZEBOV, and depletion of CD4+ T cells during vaccination caused a complete loss of glycoprotein-specific antibodies and abrogated vaccine protection.