A
Andreas Wilm
Researcher at Genome Institute of Singapore
Publications - 48
Citations - 43460
Andreas Wilm is an academic researcher from Genome Institute of Singapore. The author has contributed to research in topics: Population & Multiple sequence alignment. The author has an hindex of 28, co-authored 46 publications receiving 37117 citations. Previous affiliations of Andreas Wilm include University College Dublin & Swiss Institute of Bioinformatics.
Papers
More filters
Journal ArticleDOI
Clustal W and Clustal X version 2.0
Mark A. Larkin,Gordon Blackshields,Nigel P. Brown,R. Chenna,Paul A. McGettigan,Hamish McWilliam,Franck Valentin,Iain M. Wallace,Andreas Wilm,Rodrigo Lopez,J.D. Thompson,Toby J. Gibson,Desmond G. Higgins +12 more
TL;DR: The Clustal W and ClUSTal X multiple sequence alignment programs have been completely rewritten in C++ to facilitate the further development of the alignment algorithms in the future and has allowed proper porting of the programs to the latest versions of Linux, Macintosh and Windows operating systems.
Journal ArticleDOI
Fast, scalable generation of high‐quality protein multiple sequence alignments using Clustal Omega
Fabian Sievers,Andreas Wilm,David Dineen,Toby J. Gibson,Kevin Karplus,Weizhong Li,Rodrigo Lopez,Hamish McWilliam,Michael Remmert,Johannes Söding,Julie D. Thompson,Desmond G. Higgins +11 more
TL;DR: A new program called Clustal Omega is described, which can align virtually any number of protein sequences quickly and that delivers accurate alignments, and which outperforms other packages in terms of execution time and quality.
Journal ArticleDOI
LoFreq: a sequence-quality aware, ultra-sensitive variant caller for uncovering cell-population heterogeneity from high-throughput sequencing datasets
Andreas Wilm,Pauline Poh Kim Aw,Denis Bertrand,Grace Hui Ting Yeo,Swee Hoe Ong,Chang Hua Wong,Chiea Chuen Khor,Rosemary Petric,Martin L. Hibberd,Niranjan Nagarajan +9 more
TL;DR: It is shown that LoFreq has near-perfect specificity, with significantly improved sensitivity compared with existing methods and can efficiently analyze deep Illumina sequencing datasets without resorting to approximations or heuristics.
Journal ArticleDOI
The nf-core framework for community-curated bioinformatics pipelines.
Philip Ewels,Alexander Peltzer,Sven Fillinger,Harshil Patel,Johannes Alneberg,Andreas Wilm,Maxime Garcia,Paolo Di Tommaso,Sven Nahnsen +8 more
TL;DR: The nf-core framework is introduced as a means for the development of collaborative, peerreviewed, best-practice analysis pipelines that can be used across all institutions and research facilities and introduces a higher degree of portability as compared to custom in-house scripts.
Journal ArticleDOI
Sustainable data analysis with Snakemake.
Felix Mölder,Kim Philipp Jablonski,Kim Philipp Jablonski,Brice Letcher,Michael B Hall,Christopher Tomkins-Tinch,Christopher Tomkins-Tinch,Vanessa Sochat,Jan Forster,Jan Forster,Soohyun Lee,Sven Twardziok,Alexander Kanitz,Alexander Kanitz,Andreas Wilm,Manuel Holtgrewe,Sven Rahmann,Sven Nahnsen,Johannes Köster,Johannes Köster +19 more
TL;DR: It is shown how the popular workflow management system Snakemake can be used to guarantee reproducibility, and how it enables an ergonomic, combined, unified representation of all steps involved in data analysis, ranging from raw data processing, to quality control and fine-grained, interactive exploration and plotting of final results.