A
Antoine H.F.M. Peters
Researcher at Friedrich Miescher Institute for Biomedical Research
Publications - 94
Citations - 18353
Antoine H.F.M. Peters is an academic researcher from Friedrich Miescher Institute for Biomedical Research. The author has contributed to research in topics: Histone methyltransferase & Histone methylation. The author has an hindex of 47, co-authored 89 publications receiving 16830 citations. Previous affiliations of Antoine H.F.M. Peters include University of Basel & Research Institute of Molecular Pathology.
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Journal ArticleDOI
Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability.
Antoine H.F.M. Peters,Dónal O'Carroll,Harry Scherthan,Karl Mechtler,Stephan Sauer,Christian Schöfer,Klara Weipoltshammer,Michaela Pagani,Monika Lachner,Alexander Kohlmaier,Susanne Opravil,Michael P. Doyle,Maria Sibilia,Thomas Jenuwein +13 more
TL;DR: In vivo data assign a crucial role for pericentric H3-K9 methylation in protecting genome stability, and define the Suv39h HMTases as important epigenetic regulators for mammalian development.
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LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription.
Eric Metzger,Melanie Wissmann,Na Yin,Judith M. Müller,Robert Schneider,Antoine H.F.M. Peters,Thomas Günther,Reinhard Buettner,Roland Schüle +8 more
TL;DR: It is shown that lysine-specific demethylase 1 co-localizes with the androgen receptor in normal human prostate and prostate tumour and pargyline is identified as an inhibitor of LSD1, providing a mechanism by which demethylases control specific gene expression.
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Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin
Bernhard Lehnertz,Yoshihide Ueda,Alwin A.H.A. Derijck,Ulrich Braunschweig,Laura Perez-Burgos,Stefan Kubicek,Taiping Chen,En Li,Thomas Jenuwein,Antoine H.F.M. Peters +9 more
TL;DR: An evolutionarily conserved pathway between histone H3-K9 methylation and DNA methylation in mammals is demonstrated and both methylation systems are likely to be important in reinforcing the stability of heterochromatic subdomains and thereby in protecting genome integrity.
Journal ArticleDOI
Oncogene-induced senescence as an initial barrier in lymphoma development
Melanie Braig,Soyoung Lee,Christoph Loddenkemper,Cornelia Rudolph,Antoine H.F.M. Peters,Antoine H.F.M. Peters,Brigitte Schlegelberger,Harald Stein,Bernd Dörken,Bernd Dörken,Thomas Jenuwein,Clemens A. Schmitt,Clemens A. Schmitt +12 more
TL;DR: H3K9me-mediated senescence is identified as a novel Suv39h1-dependent tumour suppressor mechanism whose inactivation permits the formation of aggressive but apoptosis-competent lymphomas in response to oncogenic Ras.
Journal ArticleDOI
Partitioning and Plasticity of Repressive Histone Methylation States in Mammalian Chromatin
Antoine H.F.M. Peters,Stefan Kubicek,Karl Mechtler,Roderick J. O'Sullivan,Alwin A.H.A. Derijck,Laura Perez-Burgos,Alexander Kohlmaier,Susanne Opravil,Makoto Tachibana,Yoichi Shinkai,Joost H.A. Martens,Thomas Jenuwein +11 more
TL;DR: The data underscore the selective presence of distinct histone lysine methylation states in partitioning chromosomal subdomains but also reveal a surprising plasticity in propagating methylation patterns in eukaryotic chromatin.