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April Bai
Researcher at Celgene
Publications - 4
Citations - 199
April Bai is an academic researcher from Celgene. The author has contributed to research in topics: Aminopurine & High-Throughput Screening Assays. The author has an hindex of 4, co-authored 4 publications receiving 152 citations.
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Journal ArticleDOI
Discovery of CC-930, an orally active anti-fibrotic JNK inhibitor.
Veronique Plantevin Krenitsky,Lisa Nadolny,Mercedes Delgado,Leticia Ayala,Steven S. Clareen,Robert Hilgraf,Ronald Albers,Sayee G. Hegde,Neil R. D'sidocky,John Sapienza,Jonathan Wright,Meg Mccarrick,Sogole Bahmanyar,Philip P Chamberlain,Silvia L. Delker,Jeff Muir,David Giegel,Li Xu,Maria Celeridad,Jeff Lachowitzer,Brydon L. Bennett,Mehran F. Moghaddam,Oleg Khatsenko,Jason Katz,Rachel Fan,April Bai,Yang Tang,Michael A. Shirley,Brent Benish,Tracey Bodine,Kate Blease,Heather Raymon,Brian E. Cathers,Yoshitaka Satoh +33 more
TL;DR: This Letter describes the discovery of potent, selective, and orally active aminopurine JNK inhibitors and the identification of 1 (CC-930) as a development candidate, which is currently in Phase II clinical trial for IPF.
Journal ArticleDOI
Efficiency in Drug Discovery: Liver S9 Fraction Assay As a Screen for Metabolic Stability
TL;DR: Replacing liver microsome and hepatocyte assays with S9 assay for high throughput metabolic screening purposes provides the combined benefit of comprehensive and high quality data at a reasonable expense for drug discovery programs.
Journal ArticleDOI
Discovery and optimization of thieno[2,3-d]pyrimidines as B-Raf inhibitors.
Garrick Packard,Patrick Papa,Jennifer Riggs,Paul Erdman,Lida Tehrani,Dale Robinson,Roy L. Harris,Graziella I. Shevlin,Sophie Perrin-Ninkovic,Robert Hilgraf,Margaret A. Mccarrick,Tam Tran,Yuedi W. Fleming,April Bai,Samantha J. Richardson,Jason Katz,Yang Tang,Jim Leisten,Mehran F. Moghaddam,Brian E. Cathers,Dan Zhu,Sakata Steven T +21 more
TL;DR: Thieno[2,3-d]pyrimidines is identified as a core scaffold of small molecule B-Raf inhibitors and the SAR of analogs in this series will be described.
Journal ArticleDOI
Proposing advancement criteria for efficient DMPK triage of new chemical entities.
Ashutosh A. Kulkarni,Jennifer Riggs,Cindy Phan,April Bai,Andrew Antony Calabrese,Tao Shi,Mehran F. Moghaddam +6 more
TL;DR: A retrospective analysis on internal Celgene compounds by calculating the physicochemical properties and gathering data from several assays including solubility, rat and human liver S9 stability, Caco-2 permeability, and rat intravenous and oral pharmacokinetics identified plasma clearance to be most statistically relevant for prediction of oral exposure.