A
Arun K. Iyer
Researcher at Wayne State University
Publications - 144
Citations - 9696
Arun K. Iyer is an academic researcher from Wayne State University. The author has contributed to research in topics: Drug delivery & Cancer. The author has an hindex of 41, co-authored 136 publications receiving 7620 citations. Previous affiliations of Arun K. Iyer include Northeastern University & College of Health Sciences, Bahrain.
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Journal ArticleDOI
Exploiting the enhanced permeability and retention effect for tumor targeting.
TL;DR: Various endogenous factors that can positively impact the EPR effect in tumor tissues are discussed, as well as practical methods available in the clinical setting for augmenting the effect by use of exogenous agents.
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PD-1 and PD-L1 Checkpoint Signaling Inhibition for Cancer Immunotherapy: Mechanism, Combinations, and Clinical Outcome.
Hashem O. Alsaab,Hashem O. Alsaab,Samaresh Sau,Rami Alzhrani,Rami Alzhrani,Katyayani Tatiparti,Ketki Bhise,Sushil K. Kashaw,Sushil K. Kashaw,Arun K. Iyer,Arun K. Iyer +10 more
TL;DR: The current landscape of the PD-1/PD-L1 mechanistic role in tumor immune evasion and therapeutic outcome for cancer treatment is reviewed and the current progress in clinical trials, combination of drug therapy with immunotherapy, safety, and future of check point inhibitors for multiple types of cancer are reviewed.
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Recent advances in dendrimer-based nanovectors for tumor-targeted drug and gene delivery
Prashant Kesharwani,Arun K. Iyer +1 more
TL;DR: The present review compiles the recent advances in dendrimer-mediated drug and gene delivery to tumors by passive and active targeting principles with illustrative examples.
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Hyaluronic acid based self-assembling nanosystems for CD44 target mediated siRNA delivery to solid tumors.
TL;DR: The HA based nanosystems portend to be promising siRNA delivery vectors for systemic targeting of CD44 overexpressing cancers including tumor initiating (stem-) cells and metastatic lesions.
Journal ArticleDOI
siRNA Delivery Strategies: A Comprehensive Review of Recent Developments.
Katyayani Tatiparti,Samaresh Sau,Sushil K. Kashaw,Sushil K. Kashaw,Arun K. Iyer,Arun K. Iyer +5 more
TL;DR: This review presents a comprehensive update on the challenges of siRNA delivery and the current strategies used to develop nanoparticulate delivery systems.