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Bing-Hua Jiang
Researcher at Zhengzhou University
Publications - 234
Citations - 33133
Bing-Hua Jiang is an academic researcher from Zhengzhou University. The author has contributed to research in topics: Protein kinase B & Angiogenesis. The author has an hindex of 76, co-authored 211 publications receiving 30302 citations. Previous affiliations of Bing-Hua Jiang include Oregon Health & Science University & University of Iowa.
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Journal ArticleDOI
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
TL;DR: Hypoxia-inducible factor 1 (HIF-1) is found in mammalian cells cultured under reduced O2 tension and is necessary for transcriptional activation mediated by the erythropoietin gene enhancer in hypoxic cells.
Journal ArticleDOI
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1.
Jo A. Forsythe,Bing-Hua Jiang,Narayan V. Iyer,Faton Agani,Sandra W. Leung,Robert D. Koos,Gregg L. Semenza +6 more
TL;DR: HIF-1 is implicate in the activation of VEGF transcription in hypoxic cells and this work demonstrates the involvement of Hif-1 in theactivation of V EGF transcription.
Journal ArticleDOI
Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1
Gregg L. Semenza,Bing-Hua Jiang,Sandra W. Leung,Rosa Passantino,Jean-Paul Concordet,Pascal Maire,Agata Giallongo +6 more
TL;DR: It is demonstrated that functional hypoxia response elements in the promoters of the ALDA, ENO1, and Ldha genes consist of a pair of contiguous transcription factor binding sites at least one of which contains the core sequence 5′-RCGTG-3′ and is recognized by HIF-1.
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Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension.
TL;DR: Results provide evidence for the involvement of HIF-1 in O2 homeostasis and represent a functional characterization of the putative O2 sensor that initiates hypoxia signal transduction leading to Hif-1 expression.
Journal ArticleDOI
Dimerization, DNA Binding, and Transactivation Properties of Hypoxia-inducible Factor 1
TL;DR: Structural features of the HIF-1α subunit that are required for heterodimerization, DNA binding, and transactivation of hypoxia-inducible factor 1 are reported.