Bo Zhu

TL;DR: The updated understanding on the exhausted T cells in cancer and their potential regulatory mechanisms are overviewed and current therapeutic interventions targeting exhausted T Cells in clinical trials are discussed.

TL;DR: COVID-19 severity is associated with increased IgG response, and an immune response phenotyping based on the late IgG responded and NLR could act as a simple complementary tool to discriminate between severe and non-severe COVID- 19 patients, and further predict their clinical outcome.

TL;DR: The findings suggest that established NCC-GP150 with an optimized gene panel size and algorithm is feasible for bTMB estimation, which may serve as a potential biomarker of clinical benefit in patients with NSCLC treated with anti–PD-1 and anti-PD-L1 agents.

TL;DR: IL-17 is suggested to be a novel indicator of prognosis in the patients with colorectal carcinoma and could serve as a novel therapeutic target for coloreCTal carcinomas, and the results indicate that IL-17 producing cells may facilitate development of colorective carcinoma by fostering angiogenesis via promote VEGF production from cancer cells.

TL;DR: It is revealed that the immune microenvironment has high spatial heterogeneity such that intratumoral regional variation is as large as inter-personal variation and caution against that immunological signatures can be predicted solely from TMB or microenvironmental analysis from a single locus biopsy.