C
C.H.M. van Moorsel
Researcher at Utrecht University
Publications - 20
Citations - 743
C.H.M. van Moorsel is an academic researcher from Utrecht University. The author has contributed to research in topics: Single-nucleotide polymorphism & Idiopathic pulmonary fibrosis. The author has an hindex of 14, co-authored 20 publications receiving 668 citations.
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Journal ArticleDOI
Systemic cytokine response in patients with community-acquired pneumonia.
Henrik Endeman,Sabine C. A. Meijvis,Ger T. Rijkers,H. van Velzen-Blad,C.H.M. van Moorsel,Jan C. Grutters,Douwe H. Biesma +6 more
TL;DR: In 201 patients with pneumonia interleukin (IL)-1 receptor antagonist (IL-1RA), IL-6, IL-8 and IL-10 acted as acute phase proteins, independent of genotype, and levels of cytokines decreased rapidly after admission.
Journal ArticleDOI
Linkage between Toll-like receptor (TLR) 2 promotor and intron polymorphisms: functional effects and relevance to sarcoidosis
Marcel Veltkamp,Petal A. Wijnen,C.H.M. van Moorsel,Ger T. Rijkers,Henk J.T. Ruven,M. Heron,Otto Bekers,Anke M.E. Claessen,Marjolein Drent,J. M. M. Van Den Bosch,Jan C. Grutters +10 more
TL;DR: The data show that polymorphisms in TLR‐2 might be important in a small group of sarcoidosis patients and that their functional consequences explain partly some of the variance in cytokine pattern observed in different clinical phenotypes of this disease.
Journal ArticleDOI
Analysis of BTNL2 genetic polymorphisms in British and Dutch patients with sarcoidosis.
Paolo Spagnolo,Hiroe Sato,Jan C. Grutters,EA Renzoni,Sara E. Marshall,Henk J.T. Ruven,Athol U. Wells,Argyris Tzouvelekis,C.H.M. van Moorsel,J. M. M. Van Den Bosch,R M du Bois,Kenneth I. Welsh +11 more
TL;DR: HLA-DRB 1*14, DRB1*12, and BTNL2 haplotype 4--but not rs2076530 A--are associated with non-Löfgren sarcoidosis, however, the tight LD across the HLA complex makes it difficult to identify the precise location of the susceptibility locus/i.
Journal Article
Surfactant protein-D predicts survival in patients with idiopathic pulmonary fibrosis
TL;DR: Serum levels of surfactant protein-D showed to be a significant predictor of prognosis, even when corrected for age, sex, smoking, and lung function, in patients with idiopathic pulmonary fibrosis.
Journal ArticleDOI
Genetic variability in the IL1RN gene and the balance between interleukin (IL)-1 receptor agonist and IL-1β in idiopathic pulmonary fibrosis.
Nicole P. Barlo,C.H.M. van Moorsel,Nicoline M. Korthagen,M. Heron,Ger T. Rijkers,Henk J.T. Ruven,J. M. M. Van Den Bosch,Jan C. Grutters +7 more
TL;DR: The results show that genetic variability in the IL1RN gene may play a role in the pathogenesis of IPF and that this role may be more important than thought until recently.