Carlijn V. C. Bouten

TL;DR: Information on collagen fiber waviness and orientation could be used to develop structural models of the adventitia, providing better means for analyzing and understanding the mechanical properties of vascular wall.

TL;DR: The studies show a direct correlation between absence of LMNA proteins and nuclear fragility in living cells, and suggest that in addition to the loss of nuclear stiffness, a physical interaction between nuclear structures and the cytoskeleton is causing more general cellular weakness and emphasizes a potential key function for lamins in maintaining cellular tensegrity.

TL;DR: Calcific mineral formation and maturation results from a series of events involving the aggregation of calcifying extracellular vesicles, and the formation of microcalcifications and ultimately large calcification zones, which show that calcification morphology and the plaque’s collagen content are interlinked.

TL;DR: The function and role of EV are discussed, which may partially explain the paracrine effects observed in stem cell-based therapeutic approaches, and potential applications in tissue engineering are elaborate on.

TL;DR: The strain-based conditioning approach, using both prestrain and dynamic strains, offers new possibilities for bioreactor design and optimization of tissue properties towards a tissue-engineered aortic human heart valve replacement.