Christian A. Kunder

TL;DR: The authors demonstrated that circulating tumor DNA in the patients’ blood is suitable for this analysis, allowing for periodic monitoring of each patient without repeated invasive biopsies and facilitating individualized therapy.

TL;DR: It is shown that, although levels are very low in early-stage lung cancers, ctDNA is present prior to treatment in most patients and its presence is strongly prognostic, and a machine-learning method termed ‘lung cancer likelihood in plasma’ (Lung-CLiP) is developed, which can robustly discriminate early-Stage lung cancer patients from risk-matched controls.

TL;DR: Given its high specificity, Ig-HTS from plasma has potential clinical utility for surveillance after complete remission in patients initially achieving remission of diffuse large B-cell lymphoma.

TL;DR: It is shown that peripheral mast cells, upon activation, release stable submicrometer heparin-based particles containing tumor necrosis factor and other proteins that rapidly traffic to draining lymph nodes.

TL;DR: The central role of the MC-endothelial cell axis to immune homeostasis is emphasized by the fact that some of the most effective current treatments for inflammatory disorders are directed at interfering with this interaction.