C
Christian P. Fischer
Researcher at University of Copenhagen
Publications - 65
Citations - 10069
Christian P. Fischer is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Skeletal muscle & Insulin resistance. The author has an hindex of 45, co-authored 64 publications receiving 9150 citations. Previous affiliations of Christian P. Fischer include University of Copenhagen Faculty of Health Sciences & Copenhagen University Hospital.
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Journal ArticleDOI
IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans
Adam Steensberg,Christian P. Fischer,Charlotte Keller,Kirsten Møller,Bente Klarlund Pedersen +4 more
TL;DR: IL-6 induces an increase in cortisol and, consequently, in neutrocytosis and late lymphopenia to the same magnitude and with the same kinetics as during exercise, suggesting that muscle-derived IL-6 has a central role in exercise-induced leukocyte trafficking.
Journal Article
Interleukin-6 in acute exercise and training: what is the biological relevance?
TL;DR: Extended exercise involving a significant muscle mass in the contractile activity is necessary in order to produce a marked systemic IL-6 response, and exercise training may reduce basalIL-6 production as well as the magnitude of the acute exercise IL- 6 response by counteracting several potential stimuli of IL-8.
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Role of myokines in exercise and metabolism.
TL;DR: The present review focuses on muscle-derived cytokines, their regulation by exercise, and their possible roles in metabolism and skeletal muscle function and it discusses which cytokines should be classified as true myokines.
Journal ArticleDOI
Interleukin-6 stimulates lipolysis and fat oxidation in humans.
Gerrit van Hall,Adam Steensberg,Massimo Sacchetti,Christian P. Fischer,Charlotte Keller,Peter Schjerling,Natalie Hiscock,Kirsten Møller,Bengt Saltin,Mark A. Febbraio,Bente Klarlund Pedersen +10 more
TL;DR: The data identify IL-6 as a potent modulator of fat metabolism in humans, increasing fat oxidation and FA reesterification without causing hypertriacylglyceridemia.
Journal ArticleDOI
Brain-derived neurotrophic factor (BDNF) and type 2 diabetes
K. S. Krabbe,Anders R. Nielsen,Rikke Krogh-Madsen,Peter Plomgaard,Peter Rasmussen,Christian Erikstrup,Christian P. Fischer,Birgitte Lindegaard,A. M. W. Petersen,Sarah Taudorf,Niels H. Secher,Henriette Pilegaard,Helle Bruunsgaard,Bente Klarlund Pedersen +13 more
TL;DR: Low levels of BDNF accompany impaired glucose metabolism, and may be a pathogenetic factor involved not only in dementia and depression, but also in type 2 diabetes, potentially explaining the clustering of these conditions in epidemiological studies.