C
Christian V. Stevens
Researcher at Ghent University
Publications - 483
Citations - 14254
Christian V. Stevens is an academic researcher from Ghent University. The author has contributed to research in topics: Catalysis & Ring (chemistry). The author has an hindex of 45, co-authored 467 publications receiving 11742 citations. Previous affiliations of Christian V. Stevens include Katholieke Universiteit Leuven & University of Minnesota.
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Journal ArticleDOI
Continuous-Flow Synthesis of Phenothiazine Antipsychotics: A Feasibility Study
Marine Movsisyan,Laurens M. De Coen,Thomas S. A. Heugebaert,Arno Verlee,Bart Roman,Christian V. Stevens +5 more
TL;DR: In this paper, a continuous flow synthesis of a model phenothiazine antipsychotic using 3-chloropropionyl chloride as a central building block is presented, with the aim to present continuous flow technology as a contributor to fast and efficient syntheses of challenging APIs, that are nowadays experiencing supply disruptions and global shortages.
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Synthesis of biobased multivalent cross-linkers from a castor oil-derived C22-acyloin
TL;DR: In this article, a number of interesting biobased chemical building blocks were developed via the condensation of the C22 acyloin obtained from 10-undecenoic acid (castor oil and a non-edible oil) with mono-and bifunctional acid chlorides.
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A new synthesis of alkyl 1-alkyl-2-methylpyrrole-3-carboxylates by ring transformation of 2-chloro-2-acetimidoylbutyrolactones
Bart Kesteleyn,Erick Rosas Alonso,Christian V. Stevens,Yves Dejaegher,Maria Peristeropoulou,Tuyen Nguyen Van,Oleg G. Kulinkovich,Norbert De Kimpe +7 more
TL;DR: In this paper, the reaction of 2-chloro-2-acetimidoylbutyrolactones with sodium methoxide or sodium ethoxide in the corresponding alcohol provides a facile one-step synthesis of methyl or ethyl 1-alkyl 2-methylpyrrole-3-carboxylates from readily available starting materials.
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New synthesis of 1-[(3,4-dimethoxyphenyl)methoxymethyl]-6,7-dimethoxyisoquinoline (setigerine), a naturally occurring alkaloid, and some derivatives of papaverine
Jan Jacobs,Nguyen Van Tuyen Nguyen Van Tuyen,Peter Markusse,Christian V. Stevens,Leendert Maat,Norbert De Kimpe +5 more
TL;DR: In this article, an improved synthetic route for the preparation of the new alkaloid setigerine, isolated from Papaver setigerum DC, and some new 3,4-dihydropapaverine and papaverine derivatives is reported.
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Efficient Continuous-Flow Benzotriazole Activation and Coupling of Amino Acids
Sofie Seghers,Frederik E. A. Van Waes,Ana Cukalovic,Jean-Christophe Monbaliu,Jeroen De Visscher,Joris W. Thybaut,Thomas S. A. Heugebaert,Christian V. Stevens +7 more
TL;DR: By applying the microwave-to-flow paradigm, a library of (α-aminoacyl)amino-substituted heterocycles was continuously produced at near quantitative conversions and the reaction was scaled up successfully and led to excellent conversions for a broad range of substrates.