D
David A. Relman
Researcher at Stanford University
Publications - 333
Citations - 56633
David A. Relman is an academic researcher from Stanford University. The author has contributed to research in topics: Microbiome & Metagenomics. The author has an hindex of 90, co-authored 310 publications receiving 49513 citations. Previous affiliations of David A. Relman include University of Texas Medical Branch & The Advisory Board Company.
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Journal ArticleDOI
Diversity of the human intestinal microbial flora.
Paul B. Eckburg,Elisabeth M. Bik,Charles N. Bernstein,Elizabeth Purdom,Les Dethlefsen,Michael Sargent,Steven R. Gill,Karen E. Nelson,David A. Relman,David A. Relman,David A. Relman +10 more
TL;DR: A majority of the bacterial sequences corresponded to uncultivated species and novel microorganisms, and significant intersubject variability and differences between stool and mucosa community composition were discovered.
Journal ArticleDOI
Metagenomic Analysis of the Human Distal Gut Microbiome
Steven R. Gill,Mihai Pop,Robert T. DeBoy,Paul B. Eckburg,Paul B. Eckburg,Peter J. Turnbaugh,Buck S. Samuel,Jeffrey I. Gordon,David A. Relman,David A. Relman,Claire M. Fraser-Liggett,Karen E. Nelson +11 more
TL;DR: Using metabolic function analyses of identified genes, the human genome is compared with the average content of previously sequenced microbial genomes and humans are superorganisms whose metabolism represents an amalgamation of microbial and human attributes.
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Development of the human infant intestinal microbiota.
Chana Palmer,Elisabeth M. Bik,Daniel B. DiGiulio,Daniel B. DiGiulio,David A. Relman,David A. Relman,Patrick O. Brown +6 more
TL;DR: A microarray is designed to detect and quantitate the small subunit ribosomal RNA (SSU rRNA) gene sequences of most currently recognized species and taxonomic groups of bacteria and suggested that incidental environmental exposures play a major role in determining the distinctive characteristics of the microbial community in each baby.
Journal ArticleDOI
The Pervasive Effects of an Antibiotic on the Human Gut Microbiota, as Revealed by Deep 16S rRNA Sequencing
TL;DR: Ciprofloxacin treatment influenced the abundance of about a third of the bacterial taxa in the gut, decreasing the taxonomic richness, diversity, and evenness of the community, and support the hypothesis of functional redundancy in the human gut microbiota.
Journal ArticleDOI
Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation
Les Dethlefsen,David A. Relman +1 more
TL;DR: The effect of ciprofloxacin on the gut microbiota was profound and rapid, with a loss of diversity and a shift in community composition occurring within 3–4 d of drug initiation and 1 wk after the end of each course, but the return was often incomplete.