D
David Colquhoun
Researcher at University of Queensland
Publications - 296
Citations - 29196
David Colquhoun is an academic researcher from University of Queensland. The author has contributed to research in topics: Pravastatin & Nicotinic agonist. The author has an hindex of 78, co-authored 291 publications receiving 27861 citations. Previous affiliations of David Colquhoun include University of York & Repatriation General Hospital.
Papers
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Journal ArticleDOI
Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels
Andrew Tonkin,P. Alyward,David Colquhoun,Paul Glasziou,P. Harris,D. Hunt,Anthony C Keech,Stephen MacMahon,P. Magnus,D. Newel,P. Nestel,N. Sharpe,J. Shaw,R. J. Simes,P. Thompson,Alexis A. Thompson,Malcolm J. West,H. White,S. Simes,Wendy Hague,Sue Caleo,Jane Hall,Andrew J. Martin,S. Mulray,Philip J. Barter,Lawrence J. Beilin,Rory Collins,John J McNeil,Petra Meier,H. Willimott,D. Smithers,P. Wallace,J. Baker,M. Hobbs,David R. Sullivan,N. Anderson,Graeme J. Hankey,John D.G. Watson,M. Arulchelvam,S. Chup,John Daly,J. Hanna,A. Leach,M. Lee,J. Loughhead,H. Lundie-Jenkin,J. Morrison,S. Netting,A. Nguyen,H. Pater,R. Philip,G. Pinna,D. Rattos,S. Ryerson,V. Sazhin,Richard Walsh,A. Claque,M. Mackie,Julie Jane Yallop,K. Boss,M. Shepard,J. Leach,M. Gandy,J. Joughin,J. Seabrook,R. Abraham,J. Allen,F. Bates,I. Beinart,E. Breed,D. Brown,N. Bunyan,D. Calvert,T. Campbell,D. Condon-Paoloni,B. Conway,Lucy A. Coupland,J. Crowe,N. Cunio,B. Cuthbert,N. Cuthbert,S. D'Arcy,Patricia M. Davidson,B. Dwyer,J. England,C. Friend,Greg Fulcher,S. Grant,K. Hellestrand,M. Kava,Leonard Kritharides,D. McGill,H. McKee,Allan J. McLean,M. Neaverson,G. Nelson,M. O'Neill,C. Onuma,F. O'Reilly +98 more
TL;DR: Pravastatin therapy reduced mortality from coronary heart disease and overall mortality, as compared with the rates in the placebo group, as well as the incidence of all prespecified cardiovascular events in patients with a history of myocardial infarction or unstable angina who had a broad range of initial cholesterol levels.
Book ChapterDOI
Fitting and Statistical Analysis of Single-Channel Records
David Colquhoun,Fred J. Sigworth +1 more
TL;DR: The aims of analysis of single channel records can be considered in two categories: to allow one to observe results at leisure in order to determine their qualitative features and to allow highly automated methods of analysis to be fulfilled.
Journal ArticleDOI
A P2X purinoceptor expressed by a subset of sensory neurons
Chih-Cheng Chen,Armen N. Akopian,Lucia G. Sivilotti,David Colquhoun,Geoffrey Burnstock,John N. Wood +5 more
TL;DR: The remarkable selectivity of expression of the channel coupled with its sensory neuron-like pharmacology suggests that this channel may transduce ATP-evoked nociceptor activation.
Journal ArticleDOI
Binding, gating, affinity and efficacy: The interpretation of structure-activity relationships for agonists and of the effects of mutating receptors
TL;DR: Making this distinction between ecacy has no upper limit in principle, and that when it is large, changes in it are indistinguishable from changes in anity is arguably the fundamental problem of modern molecular studies of receptors.
Journal ArticleDOI
ATP receptor-mediated synaptic currents in the central nervous system
TL;DR: The recording of evoked and miniature synaptic currents in the rat medial habenula showed that they were mediated by a ligand-activated ion channel rather than a second messenger system, thus limiting the known transmitter candidates.