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David M. Gonzalez
Researcher at Brown University
Publications - 3
Citations - 1215
David M. Gonzalez is an academic researcher from Brown University. The author has contributed to research in topics: Medicine & Transcription factor. The author has an hindex of 1, co-authored 1 publications receiving 914 citations.
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Journal ArticleDOI
Signaling mechanisms of the epithelial-mesenchymal transition
TL;DR: This review discusses how intracellular pathways and extracellular signals that regulate gene expression to induce EMT crosstalk and respond to signals from the microenvironment to regulate the expression and function of EMT-inducing transcription factors in development, physiology, and disease.
Journal ArticleDOI
PPARdelta activation induces metabolic and contractile maturation of human pluripotent stem-cell-derived cardiomyocytes.
Nadeera Wickramasinghe,David H. Sachs,Bhavana Shewale,David M. Gonzalez,Priyanka Dhanan-Krishnan,Denis Torre,Elizabeth LaMarca,Serena Raimo,Rafael Dariolli,Madhavika N. Serasinghe,Joshua Mayourian,Robert Sebra,Kristin G. Beaumont,Srinivas Iyengar,Deborah L. French,Arne Hansen,Thomas Eschenhagen,Jerry E. Chipuk,Eric A. Sobie,Adam Jacobs,Schahram Akbarian,Harry Ischiropoulos,Avi Ma'ayan,Sander M. Houten,Kevin Costa,Nicole Dubois +25 more
TL;DR: In this paper , peroxisome-proliferator-associated receptor (PPAR) signaling regulates glycolysis and fatty acid oxidation (FAO) in an isoform-specific manner.
Journal ArticleDOI
Dissecting mechanisms of chamber-specific cardiac differentiation and its perturbation following retinoic acid exposure.
David M. Gonzalez,Nadine Schrode,Tasneem A M Ebrahim,Nicolas Broguiere,Giuliana Rossi,Lika Drakhlis,Robert Zweigerdt,Matthias P. Lutolf,Kristin G. Beaumont,Robert Sebra,Nicole Dubois +10 more
TL;DR: It is found that progression towards differentiated cardiomyocytes occurs primarily based on heart field progenitor identity, and that progenitors contribute to ventricular or atrial identity through distinct differentiation mechanisms.