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David R. Critchley
Researcher at University of Leicester
Publications - 166
Citations - 18701
David R. Critchley is an academic researcher from University of Leicester. The author has contributed to research in topics: Integrin & Focal adhesion. The author has an hindex of 72, co-authored 166 publications receiving 17451 citations. Previous affiliations of David R. Critchley include University of Nottingham.
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Journal ArticleDOI
Rapid leukocyte migration by integrin-independent flowing and squeezing
Tim Lämmermann,Bernhard L. Bader,Susan J. Monkley,Tim Worbs,Roland Wedlich-Söldner,Karin Hirsch,Markus Keller,Reinhold Förster,David R. Critchley,Reinhard Fässler,Michael Sixt +10 more
TL;DR: It is shown here that functional integrins do not contribute to migration in three-dimensional environments, and these cells migrate by the sole force of actin-network expansion, which promotes protrusive flowing of the leading edge.
Journal ArticleDOI
Focal adhesions - the cytoskeletal connection.
TL;DR: The role played by a subset of actin-binding proteins in coupling integrins to cytoskeletal actin and in assembling signalling complexes that are important for cell motility and cell proliferation are highlighted.
Journal ArticleDOI
Calpain-mediated proteolysis of talin regulates adhesion dynamics
Santos J. Franco,Mary A. Rodgers,Benjamin J. Perrin,Jaewon Han,David A. Bennin,David R. Critchley,Anna Huttenlocher +6 more
TL;DR: It is demonstrated that disassembly of other adhesion components, including paxillin, vinculin and zyxin, is also dependent on the ability of calpain to cleave talin, suggesting a general role for talin proteolysis in regulating adhesion turnover.
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Structural determinants of integrin recognition by talin
Begoña García-Álvarez,José M. de Pereda,David A. Calderwood,Tobias S. Ulmer,David R. Critchley,Iain D. Campbell,Mark H. Ginsberg,Robert C. Liddington +7 more
TL;DR: The crystal structure of the principal integrin binding and activating fragment of talin is reported, alone and in complex with fragments of the beta 3 integrin tail, providing structural paradigms for integrin linkage to the cell interior.
Journal ArticleDOI
Talins and kindlins: partners in integrin-mediated adhesion
TL;DR: New data reveal the domain structure of full-length talin, provide insights into talin-mediated integrin activation and show that RIAM recruits talin to the plasma membrane, whereas vinculin stabilizes talin in cell–matrix junctions.