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DavidA Gewirtz
Researcher at VCU Medical Center
Publications - 1
Citations - 2118
DavidA Gewirtz is an academic researcher from VCU Medical Center. The author has contributed to research in topics: DNA damage & Topoisomerase. The author has an hindex of 1, co-authored 1 publications receiving 2001 citations.
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A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin
TL;DR: The potential role of DNA synthesis inhibition, free radical formation and lipid peroxidation, DNA binding and alkylation, DNA cross-linking, interference with DNA strand separation and helicase activity, direct membrane effects, and the initiation of DNA damage via the inhibition of topoisomerase II in the interaction of these drugs with the tumor cell are addressed.