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Derek J. Hausenloy
Researcher at National University of Singapore
Publications - 443
Citations - 36428
Derek J. Hausenloy is an academic researcher from National University of Singapore. The author has contributed to research in topics: Myocardial infarction & Cardioprotection. The author has an hindex of 89, co-authored 412 publications receiving 31103 citations. Previous affiliations of Derek J. Hausenloy include The Heart Research Institute & Hammersmith Hospital.
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Journal ArticleDOI
Myocardial Reperfusion Injury
TL;DR: This review focuses on the mechanisms of the injury, on attempts to protect the heart against it, and on promising new approaches to cardioprotection during percutaneous coronary intervention.
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Myocardial ischemia-reperfusion injury: a neglected therapeutic target
TL;DR: A number of new therapeutic strategies currently under investigation for preventing myocardial reperfusion injury have the potential to improve clinical outcomes in patients with acute MI treated with PPCI.
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New directions for protecting the heart against ischaemia-reperfusion injury: targeting the Reperfusion Injury Salvage Kinase (RISK)-pathway.
TL;DR: Pharmacological manipulation and up-regulation of these pro-survival kinase cascades, which the authors refer to as the Reperfusion Injury Salvage Kinase (RISK) pathway, as an adjunct to reperfusion may therefore protect the myocardium from lethal reperfusions-induced cell death and provide a novel strategy to salvaging viableMyocardium and limiting infarct size.
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Inhibiting Mitochondrial Fission Protects the Heart Against Ischemia/Reperfusion Injury
Sang Bing Ong,Sapna Subrayan,Shiang Y. Lim,Derek M. Yellon,Sean M. Davidson,Derek J. Hausenloy +5 more
TL;DR: Inhibiting mitochondrial fission protects the heart against ischemia/reperfusion injury, suggesting a novel pharmacological strategy for cardioprotection.
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Postconditioning: A Form of “Modified Reperfusion” Protects the Myocardium by Activating the Phosphatidylinositol 3-Kinase-Akt Pathway
TL;DR: It is shown for the first time that ischemic Postcond protects the myocardium by activating the prosurvival kinases PI3K–Akt, eNOS, and p70S6K in accordance with the RISK pathway.