D
Dilek Colak
Researcher at Akdeniz University
Publications - 207
Citations - 6073
Dilek Colak is an academic researcher from Akdeniz University. The author has contributed to research in topics: Gene & Gene expression profiling. The author has an hindex of 33, co-authored 193 publications receiving 5119 citations. Previous affiliations of Dilek Colak include Ohio State University & Cornell University.
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Journal ArticleDOI
Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain.
Annalisa Buffo,Inmaculada Rite,Pratibha Tripathi,Alexandra Lepier,Dilek Colak,Ana Paula Horn,Tetsuji Mori,Magdalena Götz +7 more
TL;DR: It is shown by genetic fate mapping and cell type-specific viral targeting that quiescent astrocytes start to proliferate after stab wound injury and contribute to the reactive gliosis and proliferating GFAP+ cells.
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Signaling through BMPR-IA regulates quiescence and long-term activity of neural stem cells in the adult hippocampus.
Helena Mira,Helena Mira,Zoraida Andreu,Zoraida Andreu,Hoonkyo Suh,Hoonkyo Suh,D. Chichung Lie,Sebastian Jessberger,Sebastian Jessberger,Antonella Consiglio,Juana San Emeterio,Rafael Hortigüela,María Ángeles Marqués-Torrejón,Kinichi Nakashima,Kinichi Nakashima,Dilek Colak,Magdalena Götz,Isabel Fariñas,Fred H. Gage +18 more
TL;DR: It is shown that bone morphogenetic protein (BMP) signaling is active in hippocampal NSCs, downstream of BMPR-IA, and is required to balance NSC quiescence/proliferation and to prevent loss of the stem cell activity that supports continuous neurogenesis in the mature hippocampus.
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Reactive Glia in the Injured Brain Acquire Stem Cell Properties in Response to Sonic Hedgehog
Swetlana Sirko,Gwendolyn Behrendt,Pia A Johansson,Pratibha Tripathi,Marcos R. Costa,Sarah Bek,Christophe Heinrich,Steffen Tiedt,Dilek Colak,Martin Dichgans,Isabel Rebekka Fischer,Nikolaus Plesnila,Matthias Staufenbiel,Christian Haass,Christian Haass,Marina Snapyan,Armen Saghatelyan,Li-Huei Tsai,Li-Huei Tsai,Andre Fischer,Kay Grobe,Leda Dimou,Magdalena Götz +22 more
TL;DR: These findings provide a molecular basis for how cells with neural stem cell lineage emerge at sites of brain injury and imply that the high levels of SHH known to enter the brain from extraneural sources after invasive injury can trigger this response.
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Adult neurogenesis requires Smad4-mediated bone morphogenic protein signaling in stem cells.
Dilek Colak,Tetsuji Mori,Monika S. Brill,Alexander Pfeifer,Sven Falk,Chu-Xia Deng,Rui Monteiro,Christine L. Mummery,Lukas Sommer,Magdalena Götz +9 more
TL;DR: In this paper, it was shown that bone morphogenic protein (BMP)-mediated signaling is active in adult neural stem cells and is crucial to initiate the neurogenic lineage in the adult mouse subependymal zone.
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Promoter-Bound Trinucleotide Repeat mRNA Drives Epigenetic Silencing in Fragile X Syndrome
Dilek Colak,Nikica Zaninovic,Michael S. Cohen,Zev Rosenwaks,Wang Yong Yang,Jeannine Gerhardt,Matthew D. Disney,Samie R. Jaffrey +7 more
TL;DR: The data link trinucleotide-repeat expansion to a form of RNA-directed gene silencing mediated by direct interactions of the trin nucleotide- Repeat RNA and DNA to fragile X syndrome.