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Domenico Santoro

Researcher at University of Messina

Publications -  293
Citations -  5725

Domenico Santoro is an academic researcher from University of Messina. The author has contributed to research in topics: Kidney disease & Medicine. The author has an hindex of 35, co-authored 258 publications receiving 4452 citations. Previous affiliations of Domenico Santoro include Cedars-Sinai Medical Center & University of Padua.

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Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens

Krzysztof Kiryluk, +91 more
- 01 Nov 2014 - 
TL;DR: A genome-wide association study of IgA nephropathy (IgAN), the most common form of glomerulonephritis, with discovery and follow-up in 20,612 individuals of European and East Asian ancestry is performed, suggesting a possible role for host–intestinal pathogen interactions in shaping the genetic landscape of IgAN.
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Vascular access for hemodialysis: current perspectives.

TL;DR: A well-functioning vascular access (VA) is a mainstay to perform an efficient hemodialysis (HD) procedure and has the lowest association with morbidity and mortality, and for this reason AVF use is strongly recommended by guidelines from different countries.
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The copy number variation landscape of congenital anomalies of the kidney and urinary tract

Miguel Verbitsky, +94 more
- 01 Jan 2019 - 
TL;DR: Genome-wide analysis of copy number variants in 2,824 cases across the phenotypic spectrum of CAKUT sheds light on the genomic architecture of disease and identifies TBX6 as a driver forCAKUT subphenotypes in the 16p11.2 microdeletion syndrome.
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Uremic autonomic neuropathy studied by spectral analysis of heart rate

TL;DR: The study indicates that the current opinion of a major parasympathetic damage in chronic uremic patients on hemodialysis has to be modified in favor of a more widespread autonomic dysfunction involving both the sympathetic and parASYmpathetic pathways.
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Treatment of metabolic acidosis with sodium bicarbonate delays progression of chronic kidney disease: the UBI Study.

TL;DR: In persons with CKD 3–5 without advanced stages of chronic heart failure, treatment of metabolic acidosis with sodium bicarbonate is safe and improves kidney and patient survival, and there were no significant effect of SB on blood pressure, total body weight or hospitalizations.