D
Donald E. Ingber
Researcher at Boston Children's Hospital
Publications - 643
Citations - 112063
Donald E. Ingber is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Extracellular matrix & Cytoskeleton. The author has an hindex of 164, co-authored 610 publications receiving 100682 citations. Previous affiliations of Donald E. Ingber include University of Cologne & Michigan State University.
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Geometric control of cell life and death.
TL;DR: Human and bovine capillary endothelial cells were switched from growth to apoptosis by using micropatterned substrates that contained extracellular matrix-coated adhesive islands of decreasing size to progressively restrict cell extension.
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Reconstituting Organ-Level Lung Functions on a Chip
Dongeun Huh,Benjamin D. Matthews,Akiko Mammoto,Martin Montoya-Zavala,Martin Montoya-Zavala,Hong Yuan Hsin,Donald E. Ingber,Donald E. Ingber,Donald E. Ingber +8 more
TL;DR: Mechanically active “organ-on-a-chip” microdevices that reconstitute tissue-tissue interfaces critical to organ function may expand the capabilities of cell culture models and provide low-cost alternatives to animal and clinical studies for drug screening and toxicology applications.
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Mechanotransduction across the cell surface and through the cytoskeleton
TL;DR: The results suggest that integrins act as mechanoreceptors and transmit mechanical signals to the cytoskeleton, which may be mediated simultaneously at multiple locations inside the cell through force-induced rearrangements within a tensionally integrated cytos skeleton.
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Soft Lithography in Biology and Biochemistry
TL;DR: Soft lithography offers the ability to control the molecular structure of surfaces and to pattern the complex molecules relevant to biology, to fabricate channel structures appropriate for microfluidics, and topattern and manipulate cells.
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Microfluidic organs-on-chips
TL;DR: A microfluidic cell culture device created with microchip manufacturing methods that contains continuously perfused chambers inhabited by living cells arranged to simulate tissue- and organ-level physiology has great potential to advance the study of tissue development, organ physiology and disease etiology.