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Ephraim J. Fuchs
Researcher at Johns Hopkins University
Publications - 244
Citations - 14295
Ephraim J. Fuchs is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Transplantation & Graft-versus-host disease. The author has an hindex of 53, co-authored 232 publications receiving 12276 citations. Previous affiliations of Ephraim J. Fuchs include Johns Hopkins University School of Medicine.
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Journal ArticleDOI
HLA-Haploidentical Bone Marrow Transplantation for Hematologic Malignancies Using Nonmyeloablative Conditioning and High-Dose, Posttransplantation Cyclophosphamide
Leo Luznik,Paul O'Donnell,Paul O'Donnell,Heather J. Symons,Allen R. Chen,M. Susan Leffell,Marianna Zahurak,Ted Gooley,Ted Gooley,S Piantadosi,Michele Kaup,Richard F. Ambinder,Carol Ann Huff,William Matsui,Javier Bolaños-Meade,Ivan Borrello,Jonathan D. Powell,Elizabeth Harrington,Sandy Warnock,Mary E.D. Flowers,Mary E.D. Flowers,Robert A. Brodsky,Brenda M. Sandmaier,Brenda M. Sandmaier,Rainer Storb,Rainer Storb,Richard J. Jones,Ephraim J. Fuchs +27 more
TL;DR: Nonmyeloablative HLA-haploidentical BMT with posttransplantation Cy is associated with acceptable rates of fatal graft failure and severe aGVHD or cGVHD, and there was a trend toward a lower risk of extensive chronic GVHD (cGVHD) among recipients of 2 versus 1 dose of posttrans transplantation Cy.
Journal ArticleDOI
Haploidentical transplant with posttransplant cyclophosphamide vs matched unrelated donor transplant for acute myeloid leukemia
Stefan O. Ciurea,Mei-Jie Zhang,Andrea Bacigalupo,Asad Bashey,Frederick R. Appelbaum,Omar S. Aljitawi,Philippe Armand,Joseph H. Antin,Junfang Chen,Steven M. Devine,Daniel H. Fowler,Leo Luznik,Ryotaro Nakamura,Paul O'Donnell,Miguel-Angel Perales,Sai Ravi Pingali,David L. Porter,Marcie L. Riches,Olle Ringdén,Vanderson Rocha,Ravi Vij,Daniel J. Weisdorf,Richard E. Champlin,Mary M. Horowitz,Ephraim J. Fuchs,Mary Eapen +25 more
TL;DR: It is suggested that survival for patients with AML after haploidentical transplantation with posttransplant cyclophosphamide is comparable with matched unrelated donor transplantation.
Journal ArticleDOI
Alternative donor transplantation after reduced intensity conditioning: results of parallel phase 2 trials using partially HLA-mismatched related bone marrow or unrelated double umbilical cord blood grafts
Claudio G. Brunstein,Ephraim J. Fuchs,Shelly L. Carter,Chatchada Karanes,Luciano J. Costa,Juan Wu,Steven M. Devine,John R. Wingard,Omar S. Aljitawi,Corey Cutler,Madan Jagasia,Karen K. Ballen,Mary Eapen,Paul O'Donnell +13 more
TL;DR: These multicenter studies confirm the utility of dUCB and Haplo-marrow as alternative donor sources and set the stage for a multicenter randomized clinical trial to assess the relative efficacy of these 2 strategies.
Journal ArticleDOI
Nonmyeloablative bone marrow transplantation from partially HLA-mismatched related donors using posttransplantation cyclophosphamide
Paul O'Donnell,L. Luznik,Richard J. Jones,Georgia B. Vogelsang,Mary S. Leffell,Michele Phelps,P. Rhubart,Kathleen Cowan,S Piantadosi,Ephraim J. Fuchs +9 more
TL;DR: It is demonstrated that partially HLA-mismatched bone marrow can engraft rapidly and stably after nonmyeloablative conditioning that includes posttransplantation Cy, even among patients who reject their donor grafts.
Journal ArticleDOI
HLA-haploidentical bone marrow transplantation with posttransplant cyclophosphamide expands the donor pool for patients with sickle cell disease.
Javier Bolaños-Meade,Ephraim J. Fuchs,Leo Luznik,Sophie Lanzkron,Christopher Gamper,Richard J. Jones,Robert A. Brodsky +6 more
TL;DR: Nonmyeloablative conditioning with posttransplantation high-dose cyclophosphamide expands the donor pool, making marrow transplantation feasible for most patients with sickle cell disease, and is associated with a low risk of complications, even with haploidentical related donors.