E
Eric J. Rubin
Researcher at Harvard University
Publications - 550
Citations - 27725
Eric J. Rubin is an academic researcher from Harvard University. The author has contributed to research in topics: Medicine & Mycobacterium tuberculosis. The author has an hindex of 76, co-authored 473 publications receiving 24136 citations. Previous affiliations of Eric J. Rubin include Columbia University Medical Center & VCU Medical Center.
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Genes required for mycobacterial growth defined by high density mutagenesis
TL;DR: The use of transposon site hybridization (TraSH) is described to comprehensively identify the genes required by the causative agent, Mycobacterium tuberculosis, for optimal growth, suggesting that the minimal gene set required for survival varies greatly between organisms with different evolutionary histories.
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Genetic requirements for mycobacterial survival during infection
TL;DR: A surprisingly large fraction of these genes are unique to mycobacteria and closely related species, indicating that many of the strategies used by this unusual group of organisms are fundamentally different from other pathogens.
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PD-L1 Immunohistochemistry Assays for Lung Cancer: Results from Phase 1 of the Blueprint PD-L1 IHC Assay Comparison Project
Fred R. Hirsch,Abigail McElhinny,Dave Stanforth,James Ranger-Moore,Malinka Jansson,Karina Kulangara,William Richardson,Penny Towne,Debra Hanks,Bharathi Vennapusa,Amita Mistry,Rasika Kalamegham,Rasika Kalamegham,Steve Averbuch,James Novotny,Eric J. Rubin,Kenneth Emancipator,Ian McCaffery,J. Andrew Williams,Jill Walker,John W. Longshore,Ming-Sound Tsao,Keith M. Kerr +22 more
TL;DR: The Blueprint PD‐L1 IHC Assay Comparison Project revealed that three of the four assays were closely aligned on tumor cell staining whereas the fourth showed consistently fewer tumor cells stained, indicating that interchanging assays and cutoffs would lead to “misclassification” of PD‐ L1 status for some patients.
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Genome-wide requirements for Mycobacterium tuberculosis adaptation and survival in macrophages
TL;DR: The majority of Mycobacterium tuberculosis genes found by this analysis to be required for survival are constitutively expressed rather than regulated by macrophages, revealing the host-adapted lifestyle of an evolutionarily selected intracellular pathogen.
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Comprehensive identification of conditionally essential genes in mycobacteria
TL;DR: A technique, transposon site hybridization (TraSH), which allows rapid functional characterization by identifying the complete set of genes required for growth under different conditions by combining high-density insertional mutagenesis with microarray mapping of pools of mutants.