F
Fabio Martinon
Researcher at Harvard University
Publications - 33
Citations - 19431
Fabio Martinon is an academic researcher from Harvard University. The author has contributed to research in topics: Inflammasome & NALP3. The author has an hindex of 26, co-authored 29 publications receiving 17754 citations. Previous affiliations of Fabio Martinon include University of Lausanne.
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Journal ArticleDOI
Gout-associated uric acid crystals activate the NALP3 inflammasome
TL;DR: It is shown that MSU and CPPD engage the caspase-1-activating NALP3 (also called cryopyrin) inflammasome, resulting in the production of active interleukin (IL)-1β and IL-18 in mice deficient in the IL-1β receptor.
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The Inflammasomes: Guardians of the Body
TL;DR: The role of NLRs, and in particular the inflammasomes, in the recognition of microbial and danger components and the role they play in health and disease are discussed.
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NALP3 Forms an IL-1β-Processing Inflammasome with Increased Activity in Muckle-Wells Autoinflammatory Disorder
Laetitia Agostini,Fabio Martinon,Kimberly Burns,Michael F. McDermott,Philip N. Hawkins,Jürg Tschopp +5 more
TL;DR: It is reported that NALP2 and NalP3 associate with ASC, the CARD-containing protein Cardinal, and caspase-1 (but not casp enzyme-5), thereby forming an inflammasome with high proIL-1beta-processing activity.
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Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration.
Virginie Pétrilli,Papin S,Catherine Dostert,Annick Mayor,Fabio Martinon,Fabio Martinon,J. Tschopp +6 more
TL;DR: Evidence is provided that activation of NALP3, but not of the IPAF inflammasome, is blocked by inhibiting K+ efflux from cells, suggesting that low intracellular K+ may be the least common trigger of NalP-inflammasomes activation.
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Inflammatory Caspases: Linking an Intracellular Innate Immune System to Autoinflammatory Diseases
Fabio Martinon,Jürg Tschopp +1 more
TL;DR: Mutations in one of the scaffold proteins of the inflammasome, NALP3/Cryopyrin, are associated with autoinflammatory disorders underscoring the importance of regulating inflammatory caspase activation.