F
Frank W. Sellke
Researcher at Brown University
Publications - 623
Citations - 40857
Frank W. Sellke is an academic researcher from Brown University. The author has contributed to research in topics: Cardiopulmonary bypass & Angiogenesis. The author has an hindex of 76, co-authored 578 publications receiving 36608 citations. Previous affiliations of Frank W. Sellke include University of Washington & Beth Israel Deaconess Medical Center.
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Journal ArticleDOI
Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia
Sharon Maynard,Jiang Yong Min,Jaime R. Merchan,Kee-Hak Lim,Jianyi Li,Susanta Mondal,Towia A. Libermann,James P. Morgan,Frank W. Sellke,Isaac E. Stillman,Franklin H. Epstein,Vikas P. Sukhatme,S. Ananth Karumanchi +12 more
TL;DR: It is confirmed that placental soluble fms-like tyrosine kinase 1 (sFlt1), an antagonist of VEGF and placental growth factor (PlGF), is upregulated in preeclampsia, leading to increased systemic levels of sFlt 1 that fall after delivery, and observations suggest that excess circulating sFelt1 contributes to the pathogenesis of preeClampsia.
Journal ArticleDOI
Vascular Contributions to Cognitive Impairment and Dementia A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association
Philip B. Gorelick,Angelo Scuteri,Sandra E. Black,Charles DeCarli,Steven M. Greenberg,Costantino Iadecola,Lenore J. Launer,Stéphane Laurent,Oscar L. Lopez,David L. Nyenhuis,Ronald C. Petersen,Julie A. Schneider,Christophe Tzourio,Donna K. Arnett,David A. Bennett,Helena C. Chui,Randall T. Higashida,Ruth Lindquist,Peter M. Nilsson,Gustavo C. Román,Frank W. Sellke,Sudha Seshadri +21 more
TL;DR: This scientific statement provides an overview of the evidence on vascular contributions to cognitive impairment and dementia and provides evidence that subcortical forms of VCI with white matter hyperintensities and small deep infarcts are common and risk markers for VCI are the same as traditional risk factors for stroke.
Journal ArticleDOI
2014 AHA/ACC guideline for the management of patients with valvular heart disease: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines
Rick A. Nishimura,Catherine M Otto,Robert O. Bonow,Blase A. Carabello,John P. Erwin,Robert A. Guyton,Patrick T. O'Gara,Carlos E. Ruiz,Nikolaos J. Skubas,Paul Sorajja,Thoralf M. Sundt,James D. Thomas,Jeffrey L. Anderson,Jonathan L. Halperin,Nancy M. Albert,Biykem Bozkurt,Ralph G. Brindis,Mark A. Creager,Lesley H. Curtis,David L. DeMets,Judith S. Hochman,Richard J. Kovacs,E. Magnus Ohman,Susan J. Pressler,Frank W. Sellke,Win Kuang Shen,William G. Stevenson,Clyde W. Yancy +27 more
2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines Developed in Collaboration With the American Association for Thoracic Surgery, American Society of Echocardiography, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Anesthesiologists, and Society of Thoracic Surgeons WRITING COMMITTEE MEMBERS*
Rick A. Nishimura,Catherine M Otto,Robert O. Bonow,Blase A. Carabello,John P. Erwin,Robert A. Guyton,Patrick T. O'Gara,Carlos E. Ruiz,Nikolaos J. Skubas,Paul Sorajja,Thoralf M. Sundt,James D. Thomas,Jeffrey L. Anderson,Jonathan L. Halperin,Nancy M. Albert,Biykem Bozkurt,Ralph G. Brindis,Mark A. Creager,Lesley H. Curtis,David DeMets,Judith S. Hochman,Richard J. Kovacs,E. Magnus Ohman,Susan J. Pressler,Frank W. Sellke,Win-Kuang Shen,William G. Stevenson,Clyde W. Yancy +27 more
TL;DR: The next generation of leaders in education and research will be shaped by the experiences of those who have gone before them and will help shape the future of the profession.
Journal ArticleDOI
Soluble endoglin contributes to the pathogenesis of preeclampsia.
Shivalingappa Venkatesha,Mourad Toporsian,Chun Lam,Jun-ichi Hanai,Tadanori Mammoto,Yeon Mee Kim,Yeon Mee Kim,Yuval Bdolah,Kee-Hak Lim,Hai Tao Yuan,Towia A. Libermann,Isaac E. Stillman,Drucilla J. Roberts,Patricia A. D'Amore,Franklin H. Epstein,Frank W. Sellke,Roberto Romero,Roberto Romero,Vikas P. Sukhatme,Michelle Letarte,S. Ananth Karumanchi +20 more
TL;DR: A novel placenta-derived soluble TGF-β coreceptor, endoglin (sEng), which is elevated in the sera of preeclamptic individuals, correlates with disease severity and falls after delivery, suggest that sEng may act in concert with sFlt1 to induce severe preeclampsia.