Franz X. Bosch

TL;DR: The presence of HPV in virtually all cervical cancers implies the highest worldwide attributable fraction so far reported for a specific cause of any major human cancer, and the rationale for HPV testing in addition to, or even instead of, cervical cytology in routine cervical screening.

TL;DR: It is the right time for medical societies and public health regulators to consider the causal role of human papillomavirus infections in cervical cancer and to define its preventive and clinical implications.

TL;DR: The HPV- 16/18 AS04-adjuvanted vaccine showed high efficacy against CIN2+ associated with HPV-16/18 and non-vaccine oncogenic HPV types and substantial overall effect in cohorts that are relevant to universal mass vaccination and catch-up programmes.

TL;DR: The predominant pattern shown by cancer registries in developed countries is of a reduction in the incidence of squamous cervical cancer, and the major exception is observed in the United Kingdom, though the increasing incidence in young women has changed to a decrease in recent years.

TL;DR: Analysis of primary squamous cell carcinomas of the head and neck with respect to the presence of the retinoblastoma tumor suppressor protein, pRb, indicated a strong indication for a human papillomavirus-associated etiology of these tumors and suggested the functional inactivation of the pRB protein by the viral E7 gene product.