G
Gavril W. Pasternak
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 404
Citations - 29731
Gavril W. Pasternak is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Opioid & Opioid receptor. The author has an hindex of 90, co-authored 403 publications receiving 28604 citations. Previous affiliations of Gavril W. Pasternak include Kettering University & Johns Hopkins University.
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Journal ArticleDOI
Clinical Guidelines for the Use of Chronic Opioid Therapy in Chronic Noncancer Pain
Roger Chou,Gilbert J. Fanciullo,Perry G. Fine,Jeremy A Adler,Jane C. Ballantyne,Pamela Stitzlein Davies,Marilee I. Donovan,David A. Fishbain,Kathy M. Foley,Jeffrey Fudin,Aaron M. Gilson,Alexander Kelter,Alexander Mauskop,Patrick G. O'Connor,Steven D. Passik,Gavril W. Pasternak,Russell K. Portenoy,Ben A. Rich,Richard G. Roberts,Knox H. Todd,Christine Miaskowski +20 more
TL;DR: Safe and effective chronic opioid therapy for chronic noncancer pain requires clinical skills and knowledge in both the principles of opioid prescribing and on the assessment and management of risks associated with opioid abuse, addiction, and diversion.
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Strategies to Manage the Adverse Effects of Oral Morphine: An Evidence-Based Report
Nathan I. Cherny,Carla Ripamonti,Jose Pereira,Carol Davis,Marie Fallon,Henry J McQuay,Sebastiano Mercadante,Gavril W. Pasternak,Vittorio Ventafridda +8 more
TL;DR: Evidence-based recommendations for clinical-practice formulated by an Expert Working Group of the European Association of Palliative Care are presented, highlighting the need for careful evaluation to distinguish between morphine adverse effects from comorbidity, dehydration, or drug interactions, and initial consideration of dose reduction.
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Pharmacological mechanisms of opioid analgesics.
TL;DR: The relief of pain involves the complex interaction of at least six receptor systems, and the implications of opiate receptor multiplicity on the control of pain are discussed.
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Opiate Agonists and Antagonists Discriminated by Receptor Binding in Brain
TL;DR: Sodium enhances antagonist binding in vitro but decreases agonist binding, a qualitative difference that may be relevant to the divergent pharmacological properties of opiate agonists and antagonists.
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Mu Opioids and Their Receptors: Evolution of a Concept
TL;DR: Understanding of these morphine-like agents and their receptors has undergone an evolution in thinking over the past 35 years, which now reveals a complexity of the morphine- like agents andtheir receptors that had not been previously appreciated.