G
Ghaleb A. Husseini
Researcher at American University of Sharjah
Publications - 141
Citations - 4742
Ghaleb A. Husseini is an academic researcher from American University of Sharjah. The author has contributed to research in topics: Drug delivery & Nanocarriers. The author has an hindex of 32, co-authored 117 publications receiving 3851 citations. Previous affiliations of Ghaleb A. Husseini include Brigham Young University & Al-Quds University.
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Ultrasonic Drug Delivery – A General Review
TL;DR: There remains a need to better understand the physics of cavitation of microbubbles and the impact that such cavitation has on cells and drug-carrying vesicle and makes cell membranes and capillaries more permeable to drugs.
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Micelles and nanoparticles for ultrasonic drug and gene delivery
TL;DR: New technologies that combine the use of nanoparticles with acoustic power both in drug and gene delivery both in vitro and in vivo are summarized.
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The role of cavitation in acoustically activated drug delivery.
Ghaleb A. Husseini,Mario A. Diaz de la Rosa,Eric S. Richardson,Douglas A. Christensen,William G. Pitt +4 more
TL;DR: This study showed a strong correlation between percent drug release and subharmonic acoustic emissions, and they attribute the drug release to collapse cavitation that perturbs the structure of the micelle and releases drug.
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Factors affecting acoustically triggered release of drugs from polymeric micelles
TL;DR: Data suggest an important role of transient cavitation in drug release, which suggests that upon leaving the sonicated volume, the non-extravasated and non-internalized drug would circulate in the encapsulated form, thus preventing unwanted drug interactions with normal tissues.
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Drug delivery in pluronic micelles: effect of high-frequency ultrasound on drug release from micelles and intracellular uptake
Alexandre Marin,Hao Sun,Ghaleb A. Husseini,William G. Pitt,Douglas A. Christensen,Natalya Rapoport +5 more
TL;DR: The effect of high-frequency ultrasound on doxorubicin (DOX) release from Pluronic micelles and intracellular DOX uptake was studied for promyelocytic leukemia HL-60 cells, ovarian carcinoma drug-sensitive and multidrug-resistant (MDR) cells, and breast cancer MCF-7 cells.