G
Go Hasegawa
Researcher at Niigata University
Publications - 317
Citations - 5726
Go Hasegawa is an academic researcher from Niigata University. The author has contributed to research in topics: TCP acceleration & TCP global synchronization. The author has an hindex of 29, co-authored 307 publications receiving 5397 citations. Previous affiliations of Go Hasegawa include Osaka University & Tohoku University.
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PPARγ Mediates High-Fat Diet–Induced Adipocyte Hypertrophy and Insulin Resistance
Naoto Kubota,Yasuo Terauchi,Hiroshi Miki,Hiroyuki Tamemoto,Hiroyuki Tamemoto,Toshimasa Yamauchi,Kajuro Komeda,Shinobu Satoh,Ryosuke Nakano,Chikara Ishii,Takuya Sugiyama,Kazuhiro Eto,Yoshiharu Tsubamoto,Akira Okuno,Koji Murakami,Hisahiko Sekihara,Go Hasegawa,Makoto Naito,Yasushi Toyoshima,Satoshi Tanaka,Kunio Shiota,Toshio Kitamura,Toshiro Fujita,Osamu Ezaki,Shinichi Aizawa,Ryozo Nagai,Kazuyuki Tobe,Satoshi Kimura,Takashi Kadowaki +28 more
TL;DR: A hitherto unpredicted role for PPARγ in high-fat diet–induced obesity due to adipocyte hypertrophy and insulin resistance, which requires both alleles of PPARα, is revealed.
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Constitutive Regulation of Cardiac Fatty Acid Metabolism through Peroxisome Proliferator-activated Receptor α Associated with Age-dependent Cardiac Toxicity
Kenichi Watanabe,Hiroshi Fujii,Toshihiro Takahashi,Makoto Kodama,Yoshifusa Aizawa,Yoshimi Ohta,Teruo Ono,Go Hasegawa,Makoto Naito,Tamie Nakajima,Yuji Kamijo,Frank J. Gonzalez,Toshifumi Aoyama +12 more
TL;DR: The results presented here indicate that PPARα controls constitutive fatty acid oxidation, thus establishing a role for the receptor in cardiac fatty acid homeostasis and altered expression of fatty acid-metabolizing proteins seems to lead to myocardial damage and fibrosis.
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The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis
Koichi Hamada,Takehiko Sasaki,Pandelakis A. Koni,Miyuki Natsui,Hiroyuki Kishimoto,Junko Sasaki,Nobuyuki Yajima,Yasuo Horie,Go Hasegawa,Makoto Naito,Jun-ichi Miyazaki,Toshio Suda,Hiroshi Itoh,Kazuwa Nakao,Tak W. Mak,Toru Nakano,Akira Suzuki +16 more
TL;DR: PTEN is an important tumor suppressor gene and hereditary mutation of PTEN causes tumor-susceptibility diseases such as Cowden disease, and the Cre-loxP system is used to generate an endothelial cell-specific mutation of Pten (Tie2CrePten) in mice to show enhanced tumorigenesis due to an increase in angiogenesis driven by vascular growth factors.
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Regulation by Chemokines of Circulating Dendritic Cell Precursors, and the Formation of Portal Tract–Associated Lymphoid Tissue, in a Granulomatous Liver Disease
Hiroyuki Yoneyama,Hiroyuki Yoneyama,Kenjiro Matsuno,Yanyun Zhang,Masako Murai,Masako Murai,Meiji Itakura,Sho Ishikawa,Go Hasegawa,Makoto Naito,Hitoshi Asakura,Kouji Matsushima +11 more
TL;DR: Circulating DC precursors can migrate into a solid organ like liver, and participate in the granulomatous reaction in response to specific chemokines, and Anti-SLC antibody diminished PALT expansion while exacerbating granuloma formation.
Journal ArticleDOI
Expression of pentraxin 3 (PTX3) in human atherosclerotic lesions
Alexander Savchenko,Masaru Imamura,Riuko Ohashi,Shuying Jiang,Takashi Kawasaki,Go Hasegawa,I Emura,Hiroko Iwanari,Mina Sagara,Torao Tanaka,Takao Hamakubo,Tatsuhiko Kodama,Makoto Naito +12 more
TL;DR: Analysis of coronary arterial thrombi containing an atherosclerotic plaque component removed from patients with acute myocardial infarction and human aortic tissues with various degrees of atherosclerosis sampled from autopsy cases indicated that macrophages, mainly foam cells, expressed PTX3 in advanced atherosolic lesions, andPTX3 derived from neutrophils as well as macrophage plays an important role in atherogenesis.