G
Guohua Wang
Researcher at Harbin Institute of Technology
Publications - 76
Citations - 5199
Guohua Wang is an academic researcher from Harbin Institute of Technology. The author has contributed to research in topics: Regulation of gene expression & Computer science. The author has an hindex of 30, co-authored 66 publications receiving 4336 citations. Previous affiliations of Guohua Wang include Johns Hopkins University & Indiana University.
Papers
More filters
Journal ArticleDOI
miR2Disease: a manually curated database for microRNA deregulation in human disease
Qinghua Jiang,Yadong Wang,Yangyang Hao,Liran Juan,Mingxiang Teng,Xinjun Zhang,Meimei Li,Guohua Wang,Yunlong Liu +8 more
TL;DR: ‘miR2Disease’, a manually curated database, aims at providing a comprehensive resource of microRNA deregulation in various human diseases by reviewing more than 600 published papers.
Journal ArticleDOI
Transcription factors as readers and effectors of DNA methylation
Heng Zhu,Guohua Wang,Jiang Qian +2 more
TL;DR: Evidence is emerging to suggest that transcription factors lacking a MBD can also interact with methylated DNA, and the identification of these proteins and the elucidation of their characteristics and the biological consequences are important stepping stones towards a mechanistic understanding of methylation-mediated biological processes.
Journal ArticleDOI
Prioritization of disease microRNAs through a human phenome-microRNAome network
Qinghua Jiang,Yangyang Hao,Guohua Wang,Liran Juan,Tianjiao Zhang,Mingxiang Teng,Yunlong Liu,Yadong Wang +7 more
TL;DR: A network-based approach that can infer potential microRNA-disease associations and drive testable hypotheses for the experimental efforts to identify the roles of microRNAs in human diseases is presented.
Journal ArticleDOI
Estradiol-regulated microRNAs control estradiol response in breast cancer cells
Poornima Bhat-Nakshatri,Guohua Wang,Nikail Collins,Michael J. Thomson,Tim R. Geistlinger,Jason S. Carroll,Myles Brown,Scott M. Hammond,Edward F. Srour,Yunlong Liu,Harikrishna Nakshatri +10 more
TL;DR: It is proposed that the clinical course of ERα-positive breast cancers is dependent on the balance between E2-regulated tumor-suppressor micro RNAs and oncogenic microRNAs, and a negative-regulatory loop controlling E2 response through microRN as well as differences in E1-induced transcriptome and proteome.
Journal ArticleDOI
Alcohol exposure alters DNA methylation profiles in mouse embryos at early neurulation
TL;DR: Significant changes in methylation were seen in imprinted genes, genes known to play roles in cell cycle, growth, apoptosis, cancer, and in a large number of genes associated with olfaction, particularly in genes on chromosomes 7, 10, and X.