G
Gwynne D. Church
Researcher at University of California, San Francisco
Publications - 18
Citations - 630
Gwynne D. Church is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Lung injury & Medicine. The author has an hindex of 10, co-authored 15 publications receiving 518 citations. Previous affiliations of Gwynne D. Church include Boston Children's Hospital.
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Journal ArticleDOI
Positive fluid balance is associated with higher mortality and prolonged mechanical ventilation in pediatric patients with acute lung injury.
TL;DR: Positive fluid balance was associated with a significant increase in both mortality and prolonged duration of mechanical ventilation, independent of the presence of multiple organ system failure and the extent of oxygenation defect.
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Pulmonary Metagenomic Sequencing Suggests Missed Infections in Immunocompromised Children
Matt S. Zinter,Christopher C. Dvorak,Madeline Y. Mayday,Kensho Iwanaga,Ngoc P. Ly,Meghan E. McGarry,Gwynne D. Church,Lauren E Faricy,Courtney M. Rowan,Janet R. Hume,Marie E. Steiner,Emily D. Crawford,Charles Langelier,Katrina Kalantar,Eric D. Chow,Steve Miller,Kristin A. Shimano,Alexis Melton,Gregory A. Yanik,Anil Sapru,Anil Sapru,Joseph L. DeRisi +21 more
TL;DR: Zinter et al. as mentioned in this paper developed a highly sensitive metagenomic next-generation sequencing (mNGS) assay capable of evaluating the pulmonary microbiome and identifying diverse pathogens in the lungs of immunocompromised children.
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Plasma receptor for advanced glycation end-products predicts duration of ICU stay and mechanical ventilation in patients after lung transplantation
Carolyn S. Calfee,Marie Budev,Michael A. Matthay,Gwynne D. Church,Sandra Brady,Tokujiro Uchida,Akitoshi Ishizaka,Abigail R. Lara,Justin L. Ranes,M DeCamp,Alejandro C. Arroliga +10 more
TL;DR: Higher levels of plasma RAGE measured shortly after reperfusion predicted poor short-term outcomes from lung transplantation, and may have both pathogenetic and prognostic value in patients after Lung transplantation.
Journal ArticleDOI
Blood product transfusions and clinical outcomes in pediatric patients with acute lung injury
TL;DR: The transfusion of FFP is associated with an increased risk of mortality in children with ALI, independent of the severity of hypoxemia (Pao2/Fio2), presence of multiple organ system failure or disseminated intravascular coagulation.
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Higher urine desmosine levels are associated with mortality in patients with acute lung injury
Dana E. McClintock,Barry Starcher,Mark D. Eisner,B. Taylor Thompson,Doug Hayden,Gwynne D. Church,Michael A. Matthay +6 more
TL;DR: Patients with acute lung injury ventilated with lower tidal volumes have lower urine desmosine levels, a finding that may reflect reduced extracellular matrix breakdown.