H
Hegui Gong
Researcher at Shanghai University
Publications - 95
Citations - 3783
Hegui Gong is an academic researcher from Shanghai University. The author has contributed to research in topics: Alkyl & Aryl. The author has an hindex of 25, co-authored 85 publications receiving 2560 citations. Previous affiliations of Hegui Gong include Tongji University & University of North Carolina at Chapel Hill.
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Nickel-catalyzed reductive coupling of alkyl halides with other electrophiles: concept and mechanistic considerations
TL;DR: In this paper, the authors summarized the advances in the formation of C(sp3)−C(sp 3) bonds between two alkyl electrophiles, with emphasis on the control of chemoselectivity that is exceedingly challenging to achieve due to similar structures and reactivities of two unactivated alkal halides.
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Nickel-Catalyzed Reductive Couplings
TL;DR: This chapter first emphasizes the recent progress on the Ni-catalyzed alkylation, arylation/vinylation, and acylation of alkyl electrophiles, and the coupling of aryl halides with other C(sp2)–electrophiles.
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Ni-Catalyzed Reductive Coupling of Alkyl Acids with Unactivated Tertiary Alkyl and Glycosyl Halides
TL;DR: The reductive strategy is applicable to α-selective synthesis of saturated, fully oxygenated C-acyl glycosides through easy manipulations of the readily available sugar bromides and alkyl acids, avoiding otherwise difficult multistep conversions.
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Diastereoselective Ni-catalyzed Negishi cross-coupling approach to saturated, fully oxygenated C-alkyl and C-aryl glycosides
Hegui Gong,Michel R. Gagné +1 more
TL;DR: The collective studies suggest that stereochemical control of the C-glycosides is dependent on the substrate and catalysts combination, as demonstrated by its use in the first total synthesis of the natural product salmochelin SX.
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Nickel-Catalyzed Reductive Coupling of Aryl Bromides with Tertiary Alkyl Halides
TL;DR: A mild Ni-catalyzed reductive arylation of tertiary alkyl halides with aryl bromides has been developed that delivers products bearing all-carbon quaternary centers in moderate to excellent yields with excellent functional group tolerance.