H
Hervé Tettelin
Researcher at University of Maryland, Baltimore
Publications - 160
Citations - 29922
Hervé Tettelin is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 56, co-authored 146 publications receiving 27767 citations. Previous affiliations of Hervé Tettelin include TigerLogic & J. Craig Venter Institute.
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Journal ArticleDOI
Life with 6000 Genes
André Goffeau,Bart Barrell,Howard Bussey,Ronald W. Davis,Bernard Dujon,Horst Feldmann,Francis Galibert,J D Hoheisel,Claude Jacq,Mark Johnston,Edward J. Louis,Hans-Werner Mewes,Yasufumi Murakami,Peter Philippsen,Hervé Tettelin,Stephen G. Oliver +15 more
TL;DR: The genome of the yeast Saccharomyces cerevisiae has been completely sequenced through a worldwide collaboration and provides information about the higher order organization of yeast's 16 chromosomes and allows some insight into their evolutionary history.
Journal ArticleDOI
Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae: Implications for the microbial “pan-genome”
Hervé Tettelin,Vega Masignani,Michael J. Cieslewicz,Claudio Donati,Duccio Medini,Naomi L. Ward,Samuel V. Angiuoli,Jonathan Crabtree,Amanda L. Jones,A. Scott Durkin,Robert T. DeBoy,Tanja M. Davidsen,Marirosa Mora,Maria Scarselli,Immaculada Margarit Y Ros,Jeremy Peterson,Christopher R. Hauser,Jaideep P. Sundaram,William C. Nelson,Ramana Madupu,Lauren M. Brinkac,Robert J. Dodson,M. J. Rosovitz,Steven A. Sullivan,Sean C. Daugherty,Daniel H. Haft,Jeremy D. Selengut,Michelle L. Gwinn,Liwei Zhou,Nikhat Zafar,Hoda Khouri,Diana Radune,George Dimitrov,Kisha Watkins,Kevin J. B. O'Connor,Shannon Smith,Teresa Utterback,Owen White,Craig E. Rubens,Guido Grandi,Lawrence C. Madoff,Dennis L. Kasper,John L. Telford,Michael R. Wessels,Rino Rappuoli,Claire M. Fraser +45 more
TL;DR: The genomic sequence of six strains representing the five major disease-causing serotypes of Streptococcus agalactiae, the main cause of neonatal infection in humans, was generated and Mathematical extrapolation of the data suggests that the gene reservoir available for inclusion in the S. agalactic pan-genome is vast and that unique genes will continue to be identified even after sequencing hundreds of genomes.
Journal ArticleDOI
DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae
John F. Heidelberg,Jonathan A. Eisen,William C. Nelson,Rebecca A. Clayton,Michelle L. Gwinn,Robert J. Dodson,Daniel H. Haft,Erin Hickey,Jeremy Peterson,Lowell Umayam,Steven R. Gill,Karen E. Nelson,Timothy D. Read,Hervé Tettelin,Delwood Richardson,Maria D. Ermolaeva,Jessica Vamathevan,Steven Bass,Haiying Qin,Ioana Dragoi,Patrick Sellers,Lisa McDonald,Teresa Utterback,Robert D. Fleishmann,William C. Nierman,Owen White,Steven L. Salzberg,Hamilton O. Smith,Rita R. Colwell,Rita R. Colwell,John J. Mekalanos,J. Craig Venter,Claire M. Fraser +32 more
TL;DR: The V. cholerae genomic sequence provides a starting point for understanding how a free-living, environmental organism emerged to become a significant human bacterial pathogen.
Journal ArticleDOI
Complete Genome Sequence of a Virulent Isolate of Streptococcus pneumoniae
Hervé Tettelin,Karen E. Nelson,Ian T. Paulsen,Jonathan A. Eisen,Timothy D. Read,Scott N. Peterson,John F. Heidelberg,Robert T. DeBoy,Daniel H. Haft,Robert J. Dodson,Anthony S. Durkin,Michelle L. Gwinn,James F. Kolonay,William C. Nelson,Jeremy Peterson,Lowell Umayam,Owen White,Steven L. Salzberg,Matthew R. Lewis,Diana Radune,Erik Holtzapple,Hoda Khouri,Alex M. Wolf,T. Utterback,Cheryl L. Hansen,Lisa McDonald,Tamara Feldblyum,Samuel V. Angiuoli,T. Dickinson,Erin Hickey,Ingeborg Holt,Brendan J. Loftus,Fan Yang,Hamilton O. Smith,J. C. Venter,Brian Dougherty,Donald A. Morrison,S. K. Hollingshead,Claire M. Fraser +38 more
TL;DR: A motif identified within the signal peptide of proteins is potentially involved in targeting these proteins to the cell surface of low–guanine/cytosine Gram-positive species.
Journal ArticleDOI
Identification of vaccine candidates against serogroup B meningococcus by whole-genome sequencing.
Mariagrazia Pizza,[No Value] Scarlato,Masignani,Marzia Monica Giuliani,Beatrice Aricò,Maurizio Comanducci,Gary T. Jennings,L Baldi,Erika Bartolini,Barbara Capecchi,CL Galeotti,Enrico Luzzi,Roberto Manetti,Elisa Marchetti,Marirosa Mora,Sandra Nuti,Giulio Ratti,Laura Santini,Silvana Savino,Maria Scarselli,E Storni,PJ Zuo,M Broeker,E Hundt,B Knapp,E Blair,Tanya Mason,Hervé Tettelin,Derek W. Hood,AC Jeffries,Nigel J. Saunders,Dan M. Granoff,J. C. Venter,E R Moxon,Guido Grandi,Rino Rappuoli +35 more
TL;DR: The entire genome sequence of a virulent serogroup B strain was used to identify vaccine candidates and allowed the identification of proteins that are surface exposed, that are conserved in sequence across a range of strains, and that induce a bactericidal antibody response, a property known to correlate with vaccine efficacy in humans.