H
Hiroshi Nikaido
Researcher at University of California, Berkeley
Publications - 241
Citations - 44741
Hiroshi Nikaido is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: Bacterial outer membrane & Efflux. The author has an hindex of 103, co-authored 241 publications receiving 41880 citations. Previous affiliations of Hiroshi Nikaido include University of California, Davis.
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Journal ArticleDOI
Molecular Basis of Bacterial Outer Membrane Permeability Revisited
TL;DR: This review summarizes the development in the field since the previous review and begins to understand how this bilayer of the outer membrane can retard the entry of lipophilic compounds, owing to increasing knowledge about the chemistry of lipopolysaccharide from diverse organisms and the way in which lipopoly Saccharide structure is modified by environmental conditions.
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Molecular basis of bacterial outer membrane permeability.
Hiroshi Nikaido,Martti Vaara +1 more
TL;DR: It is becoming increasingly clear that the outer membrane is very important in the physiology of gram-negative bacteria in making them resistant to host defense factors such as lysozyme, P-lysin, and various leukocyte proteins.
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The Envelope of Mycobacteria
TL;DR: Differences in mycolic acid structure may affect the fluidity and permeability of the bilayer, and may explain the different sensitivity levels of various mycobacterial species to lipophilic inhibitors.
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Prevention of drug access to bacterial targets: permeability barriers and active efflux
TL;DR: As the pharmaceutical industry succeeds in producing agents that can overcome specific mechanisms of bacterial resistance, less specific resistance mechanisms such as permeability barriers and multidrug active efflux may become increasingly significant in the clinical setting.
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Multidrug Resistance in Bacteria
TL;DR: This review discusses the current knowledge on the molecular mechanisms involved in both types of resistance in bacteria.