H
Hugues Chabriat
Researcher at University of Paris
Publications - 300
Citations - 27395
Hugues Chabriat is an academic researcher from University of Paris. The author has contributed to research in topics: CADASIL & Leukoencephalopathy. The author has an hindex of 74, co-authored 286 publications receiving 23614 citations. Previous affiliations of Hugues Chabriat include Paris Diderot University & German Center for Neurodegenerative Diseases.
Papers
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Journal ArticleDOI
Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration
Joanna M. Wardlaw,Eric E. Smith,Geert J. Biessels,Charlotte Cordonnier,Franz Fazekas,Richard Frayne,Richard I. Lindley,John T. O'Brien,Frederik Barkhof,Oscar R. Benavente,Sandra E. Black,Carol Brayne,Monique M.B. Breteler,Hugues Chabriat,Charles DeCarli,Frank-Erik de Leeuw,Fergus N. Doubal,Marco Duering,Nick C. Fox,Steven M. Greenberg,Vladimir Hachinski,Ingo Kilimann,Vincent Mok,Robert J. van Oostenbrugge,Leonardo Pantoni,Oliver Speck,Blossom C. M. Stephan,Stefan J. Teipel,Anand Viswanathan,David J. Werring,Christopher Chen,Colin Smith,Mark A. van Buchem,Bo Norrving,Philip B. Gorelick,Martin Dichgans +35 more
TL;DR: This Position Paper summarises the main outcomes of this international effort to provide the STandards for ReportIng Vascular changes on nEuroimaging (STRIVE).
Journal ArticleDOI
Diffusion tensor imaging: Concepts and applications
D. Le Bihan,J.-F. Mangin,Cyril Poupon,Chris A. Clark,Sabina Pappatà,Nicolas Molko,Hugues Chabriat +6 more
TL;DR: The concepts behind diffusion tensor imaging are reviewed and potential applications, including fiber tracking in the brain, which, in combination with functional MRI, might open a window on the important issue of connectivity.
Journal ArticleDOI
Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia
Anne Joutel,Christophe Corpechot,Anne Ducros,Katayoun Vahedi,Hugues Chabriat,Philippe Mouton,Sonia Alamowitch,Valérie Domenga,Michaelle Cécillion,Emmanuelle Maréchal,Jacqueline Maciazek,Céline Vayssière,Corinne Cruaud,E. A. Cabanis,Marie Madeleine Ruchoux,Jean Weissenbach,Jean Francois Bach,Marie-Germaine Bousser,Elisabeth Tournier-Lasserve +18 more
TL;DR: The characterization of the human Notch3 gene, which was previously mapped to the CADASIL critical region, is reported, indicating that Notch 3 could be the defective protein in CADASil patients.
Journal ArticleDOI
Clinical spectrum of CADASIL: a study of 7 families
Hugues Chabriat,Katayoun Vahedi,M.G. Bousser,M. T. Iba-Zizen,Anne Joutel,A. Nibbio,T. Nagy,E. Tournier Lasserve,Marie-Odile Krebs,J. Julien,Xavier Ducrocq,M. Levasseur,Jean-Louis Mas,B. Dubois,P Homeyer,O Lyon-Caen +15 more
TL;DR: In this paper, the authors studied 148 subjects belonging to seven families by magnetic resonance imaging and genetic linkage analysis and found that all symptomatic subjects had prominent signal abnormalities on MRI with hyperintense lesions on T2-weighted images in the subcortical white matter and basal ganglia.
Journal ArticleDOI
Strong clustering and stereotyped nature of Notch3 mutations in CADASIL patients
Anne Joutel,Katayoun Vahedi,Christophe Corpechot,Alain Troesch,Hugues Chabriat,Céline Vayssière,Corinne Cruaud,Jacqueline Maciazek,Jean Weissenbach,Marie-Germaine Bousser,Jean-François Bach,Elisabeth Tournier-Lasserve +11 more
TL;DR: The findings suggest that aberrant dimerisation of Notch3, due to abnormal disulphide bridging with another NotCh3 molecule or with another protein, may be involved in the pathogenesis of this disorder.