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Iben Lundgaard
Researcher at Lund University
Publications - 35
Citations - 3420
Iben Lundgaard is an academic researcher from Lund University. The author has contributed to research in topics: Glymphatic system & Medicine. The author has an hindex of 14, co-authored 31 publications receiving 2228 citations. Previous affiliations of Iben Lundgaard include Wellcome Trust & University of Cambridge.
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The Glymphatic System: A Beginner’s Guide
TL;DR: The glymphatic system is a recently discovered macroscopic waste clearance system that utilizes a unique system of perivascular tunnels, formed by astroglial cells, to promote efficient elimination of soluble proteins and metabolites from the central nervous system.
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Aquaporin-4-dependent glymphatic solute transport in the rodent brain.
Humberto Mestre,Lauren M. Hablitz,Anna L.R. Xavier,Weixi Feng,Wenyan Zou,Tinglin Pu,Hiromu Monai,Giridhar Murlidharan,Ruth M. Castellanos Rivera,Matthew J. Simon,Martin M. Pike,Virginia Plá,Ting Du,Benjamin T. Kress,Xiaowen Wang,Benjamin A. Plog,Alexander S. Thrane,Alexander S. Thrane,Iben Lundgaard,Iben Lundgaard,Yoichiro Abe,Masato Yasui,John H. Thomas,Ming Xiao,Hajime Hirase,Aravind Asokan,Aravind Asokan,Jeffrey J. Iliff +27 more
TL;DR: It is concur that CSF influx is higher in wild-type mice than in four different Aqp4 KO lines and in one line that lacks perivascular AQP4 (Snta1 KO), and it is reported that intrastriatal injections suppress glymphatic function.
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Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism
Iben Lundgaard,Baoman Li,Lulu Xie,Hongyi Kang,Simon Sanggaard,John Douglas R Haswell,Wei Sun,Siri Goldman,Solomiya Blekot,Michael L. Nielsen,Takahiro Takano,Rashid Deane +11 more
TL;DR: It is shown, using 2-photon imaging of a near-infrared 2-deoxyglucose analogue (2DG-IR), that glucose is taken up preferentially by neurons in awake behaving mice, and the neuron is identified as the principal locus of glucose uptake as visualized by functional brain imaging.
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Neuregulin and BDNF induce a switch to NMDA receptor-dependent myelination by oligodendrocytes.
Iben Lundgaard,A. Luzhynskaya,John H. Stockley,Zhen Wang,Kimberley A. Evans,Matthew Swire,Katrin Volbracht,Hélène O. B. Gautier,Robin J.M. Franklin,Charles ffrench-Constant,David Attwell,Ragnhildur Thóra Káradóttir +11 more
TL;DR: Neuregulin switches oligodendrocytes between two modes of myelination: from a neuronal activity–independent mode to a myelin-increasing, neuronal activity-dependent, mechanism that involves glutamate release and NMDA receptor activation.
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White matter astrocytes in health and disease
TL;DR: It is suggested that specific manipulation of astrocytes could help prevent myelin pathologies and successfully restore myelin sheaths after demyelination.