Isaac S. Kohane

TL;DR: The interim integrative analysis of DNA copy number, gene expression and DNA methylation aberrations in 206 glioblastomas reveals a link between MGMT promoter methylation and a hypermutator phenotype consequent to mismatch repair deficiency in treated gliobeasts, demonstrating that it can rapidly expand knowledge of the molecular basis of cancer.

TL;DR: It is demonstrated that insulin resistance and DM associate with reduced expression of multiple nuclear respiratory factor-1 (NRF-1)-dependent genes encoding key enzymes in oxidative metabolism and mitochondrial function.

TL;DR: A genome-wide association meta-analysis of individuals with clinically assessed or self-reported depression identifies 44 independent and significant loci and finds important relationships of genetic risk for major depression with educational attainment, body mass, and schizophrenia.

TL;DR: This article showed that DNA damage is markedly increased in the promoters of genes with reduced expression in the aged cortex, and these gene promoters are selectively damaged by oxidative stress in cultured human neurons, and show reduced base-excision DNA repair.

TL;DR: This research presents a meta-modelling architecture that automates the very labor-intensive and therefore time-heavy and expensive and therefore expensive and expensive process of manually cataloging and cataloging patient-provider interactions.