J
J R McIntosh
Researcher at University of Colorado Boulder
Publications - 53
Citations - 12319
J R McIntosh is an academic researcher from University of Colorado Boulder. The author has contributed to research in topics: Microtubule & Dynein. The author has an hindex of 38, co-authored 51 publications receiving 11375 citations. Previous affiliations of J R McIntosh include Harvard University.
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Computer Visualization of Three-Dimensional Image Data Using IMOD
TL;DR: IMOD is useful for studying and modeling data from tomographic, serial section, and optical section reconstructions and allows image data to be visualized by several different methods.
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Tubulin dynamics in cultured mammalian cells.
TL;DR: The fibrous, fluorescence patterns that developed in the microinjected cells were almost indistinguishable from the pattern of microtubules seen in the same cells by indirect immunofluorescence, and mean half times of redistribution were 18-fold shorter in mitotic cells than they were in interphase cells.
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Cytoplasmic dynein is localized to kinetochores during mitosis
TL;DR: It is shown that during mitosis, cytoplasmic dynein antigens concentrate near the kinetochores, centrosomes and spindle fibres of HeLa and PtK1 cells, whereas at interphase they are distributed throughout the cy toplasm.
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Three-dimensional ultrastructural analysis of the Saccharomyces cerevisiae mitotic spindle.
Mark Winey,C L Mamay,Eileen T. O'Toole,David N. Mastronarde,Thomas H. Giddings,K L McDonald,J R McIntosh +6 more
TL;DR: The three dimensional organization of microtubules in mitotic spindles of the yeast Saccharomyces cerevisiae has been determined by computer- aided reconstruction from electron micrographs of serially cross- sectioned spindes, and interpretation of these reconstructed spindle offers some insights into the mechanisms of mitosis in this yeast.
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Model for Mitosis
TL;DR: Chromosome motion during mitosis can be explained by combining the facts available about the equilibrium between the mitotic spindle and its subunits with the postulate that the recently described cross-bridges between spindle microtubules are capable of sliding adjacent tubules over one another.