J
James N. Campbell
Researcher at Johns Hopkins University School of Medicine
Publications - 123
Citations - 14097
James N. Campbell is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Hyperalgesia & Nociception. The author has an hindex of 54, co-authored 123 publications receiving 13445 citations. Previous affiliations of James N. Campbell include Johns Hopkins University Applied Physics Laboratory & Johns Hopkins University.
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Journal ArticleDOI
Neuropathic pain Redefinition and a grading system for clinical and research purposes
Rolf-Detlef Treede,Troels S. Jensen,James N. Campbell,Giorgio Cruccu,Jonathan O. Dostrovsky,J. W. Griffin,Per Hansson,Richard A. C. Hughes,Turo Nurmikko,Jordi Serra +9 more
TL;DR: A grading system of definite, probable, and possible neuropathic pain is proposed, which includes the grade possible, which can only be regarded as a working hypothesis, and the grades probable and definite, which require confirmatory evidence from a neurologic examination.
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Mechanisms of neuropathic pain.
TL;DR: This review focuses on how both human studies and animal models are helping to elucidate the mechanisms underlying neuropathic pain, one of the surprisingly common disorders.
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Peripheral and central mechanisms of cutaneous hyperalgesia.
TL;DR: In the literature, there are some contradictions with respect to the stimulus modalities to which hyperalgesia and sensitization occur and this contradiction should spawn further investigations into the mechanical response properties of nociceptors and into the molecular mechanisms of heat sensitization.
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Evidence for two different heat transduction mechanisms in nociceptive primary afferents innervating monkey skin.
TL;DR: Two different heat transduction mechanisms in nociceptive afferents are suggested, for one, heat energy is quickly transduced into action potentials, and the peak discharge is reached soon after stimulus onset, and for the other, the transduction of heat is distinctly slower, and a peak discharge occurs near the end of the stimulus.
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Comparison of responses of warm and nociceptive C-fiber afferents in monkey with human judgments of thermal pain.
TL;DR: The results of these experiments suggest that activity in the mechanothermal nociceptive C-fibers signals the occurrence of pain evoked by radiant heat, and that the frequency of discharge in these fibers may encode the intensity of painful stimulation.