J
Jesse J. Savage
Researcher at Indiana University – Purdue University Indianapolis
Publications - 27
Citations - 911
Jesse J. Savage is an academic researcher from Indiana University – Purdue University Indianapolis. The author has contributed to research in topics: LHX3 & Pituitary gland. The author has an hindex of 13, co-authored 23 publications receiving 848 citations. Previous affiliations of Jesse J. Savage include University of Virginia & Indiana University.
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Journal ArticleDOI
Transcriptional control during mammalian anterior pituitary development
TL;DR: The transcriptional pathways that regulate the commitment of the individual pituitary cell lineages and that subsequently modulate trophic hormone gene activity in the differentiated cells of the mature gland are reviewed.
Journal ArticleDOI
Three novel missense mutations within the LHX4 gene are associated with variable pituitary hormone deficiencies
Roland Pfaeffle,Chad S. Hunter,Jesse J. Savage,Mario Durán-Prado,Rachel D. Mullen,Zachary P. Neeb,Urs Eiholzer,Volker Hesse,Nadine G. Haddad,Heike Stobbe,Werner F. Blum,Johannes F. W. Weigel,Simon J. Rhodes +12 more
TL;DR: The range of phenotypes associated with LHX4 gene mutations is extended and three novel exonic mutations in the gene are described, a relatively rare cause of combined pituitary hormone deficiency.
Journal ArticleDOI
Four novel mutations of the LHX3 gene cause combined pituitary hormone deficiencies with or without limited neck rotation.
Roland Pfaeffle,Jesse J. Savage,Chad S. Hunter,Christina Palme,Martina Ahlmann,Prasanna Kumar,J. Bellone,Eckhard Schoenau,Eckhard Korsch,Jürgen Brämswig,Heike Stobbe,Werner F. Blum,Simon J. Rhodes +12 more
TL;DR: LHX3 mutations are a rare cause of CPHD involving deficiencies for GH, prolactin, TSH, and LH/FSH in all patients, extending the known molecular defects and range of phenotypes found in LHX3-associated diseases.
Journal ArticleDOI
Neurenteric cysts of the spine
TL;DR: A systematic review of English language literature from January 1966 to December 2009 utilizing MEDLINE with the following search terminology: neurenteric cysts, enterogenous cyst, spinal cord tumor, spinal dysraphism, intraspinal Cyst, intramedullary cyst and intradural cyst is presented.
Journal ArticleDOI
A Novel LHX3 Mutation Presenting as Combined Pituitary Hormonal Deficiency
Amrit Bhangoo,Chad S. Hunter,Jesse J. Savage,Henry Anhalt,Steven Pavlakis,Emily C. Walvoord,Svetlana Ten,Simon J. Rhodes +7 more
TL;DR: The presence of a hypointense pituitary lesion and other clinical findings broadens the phenotype associated with LHX3 gene mutation, and the results of in vitro translation experiments are consistent with this prediction.