J
Jinfeng Liu
Researcher at Genentech
Publications - 93
Citations - 16353
Jinfeng Liu is an academic researcher from Genentech. The author has contributed to research in topics: Structural genomics & Gene. The author has an hindex of 49, co-authored 84 publications receiving 14839 citations. Previous affiliations of Jinfeng Liu include Columbia University & Structural Genomics Consortium.
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Journal ArticleDOI
The Transcriptional Landscape of the Mammalian Genome
Piero Carninci,Takeya Kasukawa,Shintaro Katayama,Julian Gough,Martin C. Frith,N. Maeda,Rieko Oyama,Timothy Ravasi,Boris Lenhard,Christine A. Wells,Christine A. Wells,Rimantas Kodzius,Kazuro Shimokawa,Vladimir B. Bajic,Steven E. Brenner,Serge Batalov,Alistair R. R. Forrest,Mihaela Zavolan,Melissa J. Davis,Laurens G. Wilming,Vassilis Aidinis,Jonathan E. Allen,Alberto Ambesi-Impiombato,Rolf Apweiler,Rajith N. Aturaliya,Timothy L. Bailey,Mukesh Bansal,Laura L. Baxter,Kirk W. Beisel,T. Bersano,Hidemasa Bono,Alistair M. Chalk,Kuo Ping Chiu,V. Choudhary,Alan Christoffels,D. R. Clutterbuck,Mark L. Crowe,Emiliano Dalla,Brian P. Dalrymple,Bernard de Bono,G. Della Gatta,Diego di Bernardo,Thomas A. Down,Pär G. Engström,Michela Fagiolini,Geoffrey J. Faulkner,Colin F. Fletcher,T. Fukushima,Masaaki Furuno,Sugiko Futaki,Manuela Gariboldi,P. Georgii-Hemming,Thomas R. Gingeras,Takashi Gojobori,Richard E. Green,Stefano Gustincich,Matthias Harbers,Yoshitaka Hayashi,Takao K. Hensch,Nobutaka Hirokawa,David E. Hill,Lukasz Huminiecki,M. Iacono,Kazuho Ikeo,Atsushi Iwama,T. Ishikawa,M. Jakt,Alexander Kanapin,Masaru Katoh,Yuka Imamura Kawasawa,Janet Kelso,Hiroshi Kitamura,Hiroaki Kitano,George Kollias,S. P. T. Krishnan,Adele Kruger,Sarah K. Kummerfeld,Igor V. Kurochkin,Liana F. Lareau,Dejan Lazarevic,Leonard Lipovich,Jinfeng Liu,Sabino Liuni,Sean McWilliam,M. Madan Babu,Martin Madera,Luigi Marchionni,Hideo Matsuda,Shu-ichi Matsuzawa,Harukata Miki,Flavio Mignone,Sou Miyake,Ken A. Morris,Salim Mottagui-Tabar,Salim Mottagui-Tabar,Nicola Mulder,Naoko Nakano,Hiromitsu Nakauchi,P. Ng,Roland Nilsson,S. Nishiguchi,Seishi Nishikawa,Franco Nori,Osamu Ohara,Yasushi Okazaki,Valerio Orlando,Ken C Pang,William J. Pavan,Giulio Pavesi,Graziano Pesole,Nikolai Petrovsky,Silvano Piazza,Jonathan C. Reed,James F. Reid,Brian Z. Ring,M. Ringwald,Burkhard Rost,Yijun Ruan,Steven L. Salzberg,Albin Sandelin,Claudio Schneider,Christian Schönbach,K. Sekiguchi,Colin A. Semple,Shigeto Seno,Luca Sessa,Y. Sheng,Y. Shibata,Hiroshi Shimada,Kiyo Shimada,D. Silva,B. Sinclair,Silke Sperling,Elia Stupka,Koji Sugiura,Razvan Sultana,Yoichi Takenaka,Kohei Taki,K. Tammoja,Sin Lam Tan,S. Tang,Martin S. Taylor,Jesper Tegnér,Sarah A. Teichmann,Hiroki R. Ueda,Erik van Nimwegen,Roberto Verardo,Chia-Lin Wei,Ken Yagi,H. Yamanishi,E. Zabarovsky,S. Zhu,Andreas Zimmer,Winston Hide,Carol J. Bult,Sean M. Grimmond,Rohan D. Teasdale,Edison T. Liu,Vladimir Brusic,John Quackenbush,Claes Wahlestedt,Claes Wahlestedt,John S. Mattick,David A. Hume,C. Kai,D. Sasaki,Yasuhiro Tomaru,S. Fukuda,Mutsumi Kanamori-Katayama,M. Suzuki,Junken Aoki,Taku Arakawa,J. Iida,Kengo Imamura,Masayoshi Itoh,T. Kato,Hideya Kawaji,N. Kawagashira,Tsugumi Kawashima,M. Kojima,S. Kondo,Hideaki Konno,K. Nakano,Noriko Ninomiya,T. Nishio,M. Okada,Charles Plessy,K. Shibata,Toshiyuki Shiraki,S. Suzuki,Michihira Tagami,Kazunori Waki,Akira Watahiki,Yuko Okamura-Oho,Harukazu Suzuki,Jun Kawai,Yoshihide Hayashizaki,Yoshihide Hayashizaki +197 more
TL;DR: Detailed polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome provide a comprehensive platform for the comparative analysis of mammalian transcriptional regulation in differentiation and development.
Journal ArticleDOI
Non-canonical inflammasome activation targets caspase-11
Nobuhiko Kayagaki,Søren Warming,Mohamed Lamkanfi,Lieselotte Vande Walle,Salina Louie,Jennifer Dong,Kim Newton,Yan Qu,Jinfeng Liu,Sherry Heldens,Juan Zhang,Wyne P. Lee,Merone Roose-Girma,Vishva M. Dixit +13 more
TL;DR: It is shown, with C57BL/6 Casp11 gene-targeted mice, that caspase-11 is critical for casp enzyme-1 activation and IL-1β production in macrophages infected with Escherichia coli, Citrobacter rodentium or Vibrio cholerae, and a unique pro-inflammatory role for casingase- 11 in the innate immune response to clinically significant bacterial infections is highlighted.
Journal ArticleDOI
The PredictProtein server
TL;DR: PredictProtein is an Internet service for sequence analysis and the prediction of protein structure and function that returns multiple sequence alignments, PROSITE sequence motifs, low-complexity regions (SEG), nuclear localization signals, regions lacking regular structure (NORS) and predictions of secondary structure, solvent accessibility, globular regions, transmembrane helices and functional annotations.
Journal ArticleDOI
Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7
Ingrid E. Wertz,Saritha Kusam,Cynthia Lam,Toru Okamoto,Wendy Sandoval,Daniel Anderson,Elizabeth Helgason,James A. Ernst,Mike Eby,Jinfeng Liu,Lisa D. Belmont,Joshua S. Kaminker,Karen O'Rourke,Kanan Pujara,Pawan Bir Kohli,Adam R. Johnson,Mark L. Chiu,Jennie R. Lill,Peter K. Jackson,Wayne J. Fairbrother,Somasekar Seshagiri,Mary J. C. Ludlam,Kevin G. Leong,Erin C. Dueber,Heather Maecker,David C.S. Huang,David C.S. Huang,Vishva M. Dixit +27 more
TL;DR: Highlights suggest that profiling the FBW7 and MCL1 status of tumours, in terms of protein levels, messenger RNA levels and genetic status, could be useful to predict the response of patients to antitubulin chemotherapeutics.
Journal ArticleDOI
The Genome of M. Acetivorans Reveals Extensive Metabolic and Physiological Diversity
James E. Galagan,Chad Nusbaum,Alice Roy,Matthew G. Endrizzi,Matthew G. Endrizzi,Matthew G. Endrizzi,Pendexter Macdonald,Pendexter Macdonald,Pendexter Macdonald,William Fitzhugh,Sarah E. Calvo,Reinhard Engels,Serge Smirnov,Deven Atnoor,Adam Brown,Nicole R. Allen,Nicole R. Allen,Nicole R. Allen,Jerome Naylor,Nicole Stange-Thomann,Kurt DeArellano,Robin Johnson,Lauren Linton,Paul A. McEwan,Kevin McKernan,Jessica A. Talamas,Andrea Tirrell,Andrea Tirrell,Wenjuan Ye,Wenjuan Ye,Andrew Zimmer,Robert D. Barber,Isaac K. O. Cann,David E. Graham,David A. Grahame,Adam M. Guss,Reiner Hedderich,Cheryl Ingram-Smith,Cheryl Ingram-Smith,Cheryl Ingram-Smith,H. Craig Kuettner,Joseph A. Krzycki,Joseph A. Krzycki,John A. Leigh,Weixi Li,Jinfeng Liu,Biswarup Mukhopadhyay,John N. Reeve,Kerry S. Smith,Timothy A. Springer,Timothy A. Springer,Timothy A. Springer,Lowell Umayam,Owen White,Robert H. White,Everly Conway de Macario,Everly Conway de Macario,James G. Ferry,Ken F. Jarrell,Ken F. Jarrell,Hua Jing,Hua Jing,Hua Jing,Alberto J.L. Macario,Ian T. Paulsen,Ian T. Paulsen,Ian T. Paulsen,Matthew A. Pritchett,Kevin R. Sowers,Ronald V. Swanson,Steven H. Zinder,Steven H. Zinder,Eric S. Lander,Eric S. Lander,Eric S. Lander,William W. Metcalf,Bruce W. Birren +76 more
TL;DR: The complete genome sequence of an acetate-utilizing methanogen, Methanosarcina acetivorans C2A, is reported, which indicates the likelihood of undiscovered natural energy sources for methanogenesis, whereas the presence of single-subunit carbon monoxide dehydrogenases raises the possibility of nonmethanogenic growth.