Jo Nijs

TL;DR: The hypothesis that central sensitization is also responsible for the sustaining pain complaints in CFS is proposed, based on the hyperalgesia and allodynia reported in C FS, on the elevated concentrations of nitric oxide presented in the blood of CFS patients, in addition to the typical personality styles seen in Cfs and on the brain abnormalities shown on brain images.

TL;DR: In this article, a mechanism-based clinical guidelines for the recognition of central sensitization in patients with musculoskeletal pain are provided, where the authors apply the science of nociceptive and pain processing neurophysiology to the practice of manual therapy.

TL;DR: Face-to-face sessions of pain physiology education, in conjunction with written educational material, are effective for changing pain cognitions and improving health status in patients with various chronic musculoskeletal pain disorders.

TL;DR: Overall results suggest that, although peripheral mechanisms are involved in OA pain, hypersensitivity of the CNS plays a significant role in a subgroup of subjects within this population of patients.

TL;DR: It is tempting to speculate that ongoing nociception is associated with cortical and subcortical reorganization and may play an important role in the process of the chronification of LBP.