John B. Simpson

TL;DR: The results support the relative safety of PTCA as a method of nonsurgical myocardial revascularization in carefully selected patients and nonfatal complications were significantly influenced by the presence of unstable angina and initial lesion severity > 90% diameter stenosis.

TL;DR: The response to injury in existing animal models of angioplasty may follow a very different course of events from the clinical reality in human atherosclerotic coronary arteries and may help explain why current approaches to restenosis therapy have been ineffective.

TL;DR: In this paper, a catheter device for treatment of disease in biological conduits is described, which has inner and outer coaxial catheter members, each having an inflatable balloon attached near its distal end.

TL;DR: In this article, an atherectomy device for removing stenosis materials from a vascular vessel is described, which includes a flexible tubular member, a flexible drive means disposed within the tubular part, and a cutting assembly carried by the distal extremity of the tube.

TL;DR: Using in situ hybridization and immunohistochemical methods, it is demonstrated that in addition to macrophages, smooth muscle and endothelial cells synthesize OPN mRNA and protein in human coronary atherosclerotic plaque specimens obtained by directional atherectomy, suggesting that OPN may contribute to cellular accumulations and dystrophic calcification in atherosclerosis plaques.