J
John C. Longhurst
Researcher at University of California, Irvine
Publications - 205
Citations - 9869
John C. Longhurst is an academic researcher from University of California, Irvine. The author has contributed to research in topics: Reflex & Electroacupuncture. The author has an hindex of 52, co-authored 205 publications receiving 9367 citations. Previous affiliations of John C. Longhurst include University of Texas Southwestern Medical Center & University of California, San Diego.
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Journal ArticleDOI
Effects of static muscular contraction on impulse activity of groups III and IV afferents in cats
TL;DR: The results suggest that although both groups III and IV muscle afferents contribute to the reflex cardiovascular increases evoked by static exercise, group III fibers were likely to be stimulated by the mechanical effects of muscular contraction, whereas at least some group IV fibers werelikely to be stimulating by the metabolic products of muscular contractions.
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Circulating biomarkers of inflammation, antioxidant activity, and platelet activation are associated with primary combustion aerosols in subjects with coronary artery disease.
Ralph J. Delfino,Norbert Staimer,Thomas Tjoa,Andrea Polidori,Mohammad Arhami,Daniel L. Gillen,Micheal T. Kleinman,Nosratola D. Vaziri,John C. Longhurst,Frank Zaldivar,Constantinos Sioutas +10 more
TL;DR: It is suggested that traffic emission sources of OCpri and quasi-ultrafine particles lead to increased systemic inflammation and platelet activation and decreased antioxidant enzyme activity in elderly people with CAD.
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Air Pollution Exposures and Circulating Biomarkers of Effect in a Susceptible Population: Clues to Potential Causal Component Mixtures and Mechanisms
Ralph J. Delfino,Norbert Staimer,Thomas Tjoa,Daniel L. Gillen,Andrea Polidori,Mohammad Arhami,Micheal T. Kleinman,Nosratola D. Vaziri,John C. Longhurst,Constantinos Sioutas +9 more
TL;DR: Traffic-related air pollutants are associated with increased systemic inflammation, increased platelet activation, and decreased erythrocyte antioxidant enzyme activity, which may be partly behind air pollutant–related increases in systemic inflammation.
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A Comparison of Regional Blood Flow and Oxygen Utilization During Dynamic Forearm Exercise in Normal Subjects and Patients with Congestive Heart Failure
TL;DR: At comparable levels of dynamic forearm exercise patients with CHF have an inadequate arteriolar dilation and their augmented oxygen extraction is not sufficient to prevent them from shifting more completely to anaerobic metabolism.
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Effects of capsaicin and bradykinin on afferent fibers with ending in skeletal muscle.
TL;DR: The results suggest that group IV muscle afferents are primarily responsible for causing the reflex increases in cardiovascular function evoked by injecting capsaicin into the arterial supply of the skinned hindlimb of dogs.