Johnny Ludvigsson

TL;DR: Sera from 8 out of 10 newly diagnosed diabetic children consistently immunoprecipitate a protein having a molecular weight of ∼64,000 (64K) and an additional protein was precipitated from islet cells obtained from a HLA-DR3-positive donor, suggesting that the 64K and/or 38K protein components may represent cell-specific target antigens in insulin-dependent diabetes.

TL;DR: GAD-alum may contribute to the preservation of residual insulin secretion in patients with recent-onset type 1 diabetes, although it did not change the insulin requirement.

TL;DR: A unified model in which immune tolerance to β cells can be broken by several environmental exposures that induce generation of hybrid peptides acting as neoautoantigens is suggested.

TL;DR: During the past decade the cumulative incidence of diabetic nephropathy, as manifested by persistent albuminuria, among patients who have had diabetes for 25 years has decreased substantially, probably as a result of improved glycemic control.

TL;DR: It is suggested that future studies of immunotherapeutic intervention with teplizumab might have increased success in prevention of a decline in β-cell function (measured by C-peptide) and provision of glycaemic control at reduced doses of insulin if they target patients early after diagnosis of diabetes and children.