J
Jonathan Segal
Publications - 16
Citations - 965
Jonathan Segal is an academic researcher. The author has contributed to research in topics: Genome-wide association study & Pharmacogenomics. The author has an hindex of 9, co-authored 15 publications receiving 943 citations.
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Journal ArticleDOI
Screening large-scale association study data: exploiting interactions using random forests
TL;DR: In the context of large-scale genetic association studies where unknown interactions exist among true risk-associated SNPs or SNPs and environmental covariates, screening SNPs using random forest analyses can significantly reduce the number of SNPs that need to be retained for further study compared to standard univariate screening methods.
Journal ArticleDOI
Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci.
John Verner Raelson,Randall D. Little,Andreas Ruether,Helene Fournier,Bruno Paquin,Paul Van Eerdewegh,Walter Edward Bradley,Pascal Croteau,Quynh Nguyen-Huu,Jonathan Segal,Sophie Debrus,René Allard,Philip Rosenstiel,Andre Franke,Gunnar Jacobs,Susanna Nikolaus,Jean-Michel Vidal,Peter L Szego,Nathalie Laplante,Hilary Clark,René J. A. Paulussen,John W. Hooper,Tim Keith,Abdelmajid Belouchi,Stefan Schreiber +24 more
TL;DR: A GWA study for Crohn's disease using family trios from the Quebec Founder Population identified multiple regions associated with the disease that met the criteria for genome-wide significance, with many containing a gene whose function appears relevant to CD.
Patent
Genemap of the human genes associated with crohn's disease
Abdelmajid Belouchi,John Verner Raelson,Walter Edward Bradley,Bruno Paquin,Helene Fournier,Quynh Nguyen-Huu,Pascal Croteau,Rene Allard,Sophie Debrus,Valerie Serre,Eerdewegh Paul Van,Randall David Little,Tim Keith,Jonathan Segal +13 more
TL;DR: In this paper, the selection of a set of polymorphism markers for use in genome wide association studies based on linkage disequilibrium mapping is discussed. But the present work is limited to the use of haplotype information to predict an individual's susceptibility to Crohn's disease and/or their response to a particular drug or drugs.
Patent
Genemap of the human genes associated with psoriasis
Abdelmajid Belouchi,John Verner Raelson,Walter Edward Bradley,Bruno Paquian,Quynh Nguyen-Huu,Pascal Croteau,Rene Allard,Randall David Little,Johanne Cousineau,Sophie Debrus,Tim Keith,Natali Henderson,Daniel Dubois,Paul Van Eerdewegh,Jonathan Segal +14 more
TL;DR: In this article, the selection of a set of polymorphism markers for use in genome wide association studies based on linkage disequilibrium mapping is discussed. But the present work is limited to the use of haplotype information to predict an individual's susceptibility to psoriasis disease and/or their response to a particular drug or drugs.
Patent
Genemap of the human genes associated with schizophrenia
Abdelmajid Belouchi,John Verner Raelson,Walter Edward Bradley,Bruno Paquin,Helene Fournier,Pascal Croteau,Nouzha Paquin,Daniel Dubois,Vanessa Bruat,Paul Van Eerdewegh,Jonathan Segal,Randall David Little,Tim Keith +12 more
TL;DR: In this paper, the selection of a set of polymorphism markers for use in genome wide association studies based on linkage disequilibrium mapping is discussed. But the present work is limited to the use of haplotype information to predict an individual's susceptibility to SCHIZOPHRENIA disease and/or their response to a particular drug or drugs.