K
Kay Brune
Researcher at University of Erlangen-Nuremberg
Publications - 318
Citations - 16244
Kay Brune is an academic researcher from University of Erlangen-Nuremberg. The author has contributed to research in topics: Cyclooxygenase & Pharmacokinetics. The author has an hindex of 69, co-authored 318 publications receiving 15392 citations. Previous affiliations of Kay Brune include Baxter International & Merck & Co..
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Journal ArticleDOI
Engineered heart tissue grafts improve systolic and diastolic function in infarcted rat hearts
Wolfram-Hubertus Zimmermann,Ivan Melnychenko,G Wasmeier,Michael Didié,Hiroshi Naito,Uwe Nixdorff,Andreas Hess,Lubos Budinsky,Kay Brune,Bjela Michaelis,Stefan Dhein,Alexander P. Schwoerer,Heimo Ehmke,Thomas Eschenhagen +13 more
TL;DR: This study provides evidence that large contractile cardiac tissue grafts can be constructed in vitro, can survive after implantation and can support contractile function of infarcted hearts.
Journal ArticleDOI
Cyclooxygenase-2—10 Years Later
Burkhard Hinz,Kay Brune +1 more
TL;DR: The present review assesses recent advances in COX-2 research, with particular emphasis on new insights into pathophysiological and physiological functions of this isoenzyme.
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Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man
TL;DR: In contrast to previous concepts, acetaminophen inhibited COX‐2 by more than 80%, i.e., to a degree comparable to nonste‐roidal antiinflammatory drugs (NSAIDs) and selective COx‐2 inhibitors.
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Reversal of pathological pain through specific spinal GABAA receptor subtypes.
Julia Knabl,Robert Witschi,Katharina Hösl,Heiko Reinold,Ulrike B. Zeilhofer,Seifollah Ahmadi,Seifollah Ahmadi,Johannes Brockhaus,Johannes Brockhaus,Marina Sergejeva,Andreas Hess,Kay Brune,Jean-Marc Fritschy,Uwe Rudolph,Uwe Rudolph,Hanns Möhler,Hanns Möhler,Hanns Ulrich Zeilhofer,Hanns Ulrich Zeilhofer,Hanns Ulrich Zeilhofer +19 more
TL;DR: It is shown that their selective activation by the non-sedative (‘α1-sparing’) benzodiazepine-site ligand L-838,417 is highly effective against inflammatory and neuropathic pain yet devoid of unwanted sedation, motor impairment and tolerance development.
Journal ArticleDOI
Up-regulation of cyclooxygenase-2 mRNA in the rat spinal cord following peripheral inflammation
TL;DR: COX‐2 might be regarded as the COX isozyme responsible for spinal PG release in nociceptive processing under a peripheral inflammatory stimulus.